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Jméno značky: Zovirax

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What is Zovirax?

Aciclovir is an antiviral agent with excessive in vitro efficacy in opposition to Herpes simplex virus sorts 1 and 2 and Varicella zoster virus. It is transformed within the cell by virus-induced thymidine kinase to aciclovir monophosphate, which is further transformed by mobile enzymes to the lively aciclovir triphosphate. Aciclovir triphosphate competitively inhibits the viral DNA polymerase and prevents additional viral DNA synthesis, thus blocking multiplication of the virus.

Zovirax Drug Recommendation

A cutaneous herpes infection is usually not severe and often heals spontaneously. Normally, native therapy with a detached product containing zinc oxide or zinc sulphate (probably with lidocaine) is adequate. In the case of aches, give paracetamol. In the case of acute herpes zoster neuralgia, nevertheless, begin with amitriptyline (nortriptyline for the aged). Oral antiviral therapy with a nucleoside analogue (aciclovir, famciclovir, or valaciclovir) is simply thought of for herpes virus infections in certain conditions. Contemplating the benefit of use, valaciclovir or famciclovir is mostly well-liked.

The antiviral therapy is simply helpful if begun within a certain time period after the onset of the primary signs. The size of this era depends upon the kind of infection (herpes simplex or zoster, primo-infection or relapse) and the immune standing of the affected person. For extra data, see the step-by-step plans for herpes virus per dysfunction.

Infectious Conjunctivitis: In infectious conjunctivitis brought on by a banal agent, a neighbourhood antibiotic shouldn’t be indicated, besides in teams in danger of issues (e.g., after the latest eye surgical procedure, in chronically infectious eye illness or immunocompromised sufferers) or often, if the conjunctivitis lasts longer than two weeks. In these instances, chloramphenicol eye drops and/or eye ointment are more well-liked than fusidic acid eye gel, attributable to a broader spectrum of motion and less speedy growth of resistance. In the case of herpes simplex virus conjunctivitis, aciclovir eye ointment is really useful. In the case of varicella-zoster virus conjunctivitis, check with the ophthalmologist on the identical day and begin an oral nucleoside analogue (valaciclovir or aciclovir) immediately.

Co byste měli prodiskutovat se svým lékařem před použitím tohoto léku?

  • Být těhotná
    • Teratogeneze: In people, no antagonistic results have been seen in numerous pregnancies. In animals, there may be proof of harm only at doses poisonous to the dam.
    • utilisedCan be utilized orally, together with throughout the 1st trimester, for main and recurrent genital herpes infections. Use intravenous administration solely on strict indication.

  • Laktace
    • Transition into breast milk: Sure, to a minor extent (after oral administration). The toddler might thus obtain as much as 0.3 mg/kg bw/day by way of breast milk; that is purely a small share of the authorised toddler dose. There’s inadequate expertise with intravenous use throughout lactation.
    • pharmacological impact: hostile results within the toddler have by no means been reported.
    • can be utilised safely orally, and intravenous use can be, in all probability, protected.

Kontraindikace: hypersensitivity to (val)aciclovir.

Zovirax Indications

  1. Ústní
    • Remedies for herpes simplex virus infections of the pores and skin and mucous membranes, together with preliminary and recurrent genital herpes;
    • Prophylaxis of (ceaselessly) recurring Herpes simplex infections in immunocompetent sufferers
    • Prophylaxis of Herpes simplex infections in immunocompromised sufferers 
    • Remedy of infections of the pores and skin and mucous membranes brought on by the Varicella zoster virus, equivalent to shingles, particularly if a severe course might be anticipated.

  2. Intravenózní
    • Prophylaxis and therapy of Herpes simplex infections in immunocompromised sufferers
    • Remedies for main and recurrent Varicella zoster infections when the immune response is impaired; shingles when the immune response is enough when an extreme course of the illness is predicted;
    • Remedy of extreme preliminary genital herpes, of herpes encephalitis, and of herpes simplex infections in neonates and infants as young as 3 months (herpes neonatorum).

Zovirax Drug Interactions

  1. Co-medication with nephrotoxic medicine (e.g., ciclosporin) will increase the danger of kidney harm.
  2. Aciclovir might improve with co-medication with mycophenolic acid.
  3. Neuropathy, convulsions, and lethargy might happen with concomitant use of aciclovir with zidovudine. When co-medicating with interferon a (2a and 2b) or (intrathecal) methotrexate, there may be an elevated threat of neurological uncomfortable side effects.
  4. Publicity for theophylline might improve by roughly 50% with concomitant therapy; monitor the plasma concentration of theophylline.
  5. Extremely elevated lithium ranges have been reported with excessive IV doses (case report); test lithium ranges to make sure.

Zovirax Dosage

To stop crystallisation within the kidneys, guarantee good hydration, particularly in aged patients who’re handled intravenously and/or with excessive doses of aciclovir; additionally, decide the creatinine clearance beforehand. Please note that the i.v. dosage strongly depends on kidney function.

  1. Remedy: Herpes simplex infections (together with preliminary and recurrent genital herpes)
    • Adults (incl. aged) and kids  2 years old
      • Ústní: Based on the producer: 200 mg/day every 4 hours, eliminating the evening dose for five days. In the case of extreme preliminary infection, an extended therapy interval could also be obligatory. The primary dose needs to be administered as quickly as possible after the onset of an infection, in case of recurrence throughout the prodromal interval, or as quickly as lesions seem. In severely immunocompromised individuals (e.g. after bone marrow transplant or in the case of decreased intestinal absorption), the return dose could also be doubled to 400 mg, or take into account intravenous administration.
      • I.v. infusion: 5 mg/kg physique weight every 8 hours for 5-7 days.
    • Kids  2 years previous
      • Ústní: 100 mg (2.5 ml suspension) 5/day every 4 hours, omitting the evening dose, for five days. In the case of extreme preliminary infection, a longer remedy could also be obligatory. The primary dose needs to be administered as quickly as possible after the onset of an infection. For the therapy of herpes neonatorum, infusion is really useful. See the prescription beneath that indication.
    • Kids 3 months to 12 years
      • I.v. infusion (for extreme varieties): 250 mg/m2 of physique floor space each 8 hours for 5-7 days
    • Newborns and infants as old as 3 months
      • Based on the producer, 10 mg/kg physique weight every 8 hours for 10 days.
    • untimely (gestational age  37 weeks)
      • IV infuze:
        • 60 mg/kg body weight/day divided into 3 doses
        • For pores and skin, eyes, and mouth solely: for 14 days
        • for intensive infection and/or CNS involvement for 21 days.

  2. Herpes simplex encephalitis
    • Adults and kids > 12 years
      • I.v. infusion: 10 mg/kg physique weight every 8 hours for 10 days.
      • I.v. infusion: 1500 mg/m2/day divided into 3 doses, over 14–21 days.
    • Kids 3 months to 12 years
      • IV infuze:
        • based on the producer: 500 mg/m2 of physique floor space every 8 hours for 10 days.
        • Based on the paediatric formulary of the NKFK, the above-mentioned dose is for 14–21 days.
    • A terme neonates and infants as much as 3 months.
      • I.V. infusion Based on the NKFK paediatric formulary, 80 mg/kg bw/day, divided into 4 doses, for 14–21 days.
    • untimely (gestational age  37 weeks)
      • I.V. infusion Based on the NKFK paediatric formulary, 60 mg/kg bw/day, divided into 3 doses, for 14–21 days.

  3. Prophylaxis of (ceaselessly) recurring herpes simplex infections (together with genital and labial herpes) in immunocompetent sufferers
    • Dospělí
      • Ústní: Based on the producer, 400 mg twice a day every 12 hours or 200 mg four times a day every six hours. A dose discount to 200 mg 3/day (each 8 hours) or even 2/day (each 12 hours) should still be efficient. Nevertheless, breakthrough infections might happen in some sufferers, even with a complete day-to-day dose of 800 mg. The period of prophylaxis is set by the affected person’s threat interval. In the case of long-term therapy, it’s advisable to interrupt therapy after a number of months (e.g., 6–12 months) to be able to observe doable adjustments in the pure course of the infection.

  4. Prophylaxis of Herpes simplex infections in immunocompromised individuals
    • Adults and kids  2 years old
      • Ústní: 200 mg 4/day, every 6 hours. If obligatory, double the dose to 400 mg 4/day every 6 hours in severely immunocompromised sufferers (e.g. after bone marrow transplantation) or in the case of decreased intestinal absorption, or take into account intravenous administration for them. Prophylaxis needs to be initiated at the time of decline in immune status. The period of prophylaxis is set by the affected person’s threat interval.
    • Kids  2 years previous
      • Ústní: 100 mg (2.5 ml suspension) 4/day, every 6 hours. Begin prophylaxis when the immune status is decreased. The period of prophylaxis is set by the affected person’s threat interval.

  5. Remedy for Varicella zoster infections (equivalent to shingles)
    • Dospělí
      • Ústní: 800 mg 5/day each 4 hours, eliminating the evening dose, for 7 days (10 days for herpes ophthalmicus); administer the primary dose as quickly as possible, ideally within 48 hours, after the onset of the primary symptoms and skin signs. To be able to stop eye issues, herpes zoster of the top and neck area (above the collarbone) equivalent to herpes zoster ophthalmicus and herpes zoster oticus, therapy also needs to be begun more than 72 hours after the onset of the pain and skin rash. For added data, see the section “Recommendation.”
      • IV infuze:
        • 5 mg/kg physique weight every 8 hours for 5-7 days
        • In immunocompromised patients, 10 mg/kg body weight every 8 hours.
    • Kids from 3 months
      • I.v. infusion: based on the producer from 3 months to 12 years (and regular renal function): 250 mg/m2 of physique floor each 8 hours; in immunocompromised sufferers, 500 mg/m2 of physique floor each 8 hours for 5-7 days.

  6. A terme neonates and infants as much as 3 months.
    • I.v. infusion: 80 mg/kg physique weight/day divided into 4 doses for 7 days.
    • untimely (gestational age  37 weeks)
      • I.v. infusion: 60 mg/kg physique weight/day divided into 3 doses for 7 days.

Weight problems: Elevated plasma concentrations could also be measured in overweight patients receiving intravenous aciclovir primarily based on their precise body weight. A dose discount ought to be thought of for them if they’ve impaired renal function and/or are of advanced age. In a study of seven morbidly obese patients, dosing primarily based on perfect physique weight resulted in peak concentrations roughly 29% lower than in sufferers of regular physique weight receiving a dose primarily based on whole physique weight. The consequences of the decreased peak concentrations on efficacy are unknown.

Zovirax Precautions

Use caution with current neurological problems, extreme hypoxia, liver or electrolyte abnormalities.

  1. The danger of neurological uncomfortable side effects will increase in the aged and with decreased renal function. Test fastidiously for these. They often disappear after therapy is stopped.
  2. Hostile results on the kidneys: Make sure there is enough fluid consumption with excessive oral doses and with intravenous administration. Because of the threat of renal antagonistic reactions after intravenous administration, monitor the affected person’s urine output for a number of hours. Take into account a dose discount for intravenous utility of aciclovir in weight problems together with pre-existing impaired renal function.
    • Renal impairment often responds quickly to an affected person’s rehydration and/or dose discount or discontinuation of aciclovir therapy.
    • In youngsters, the blood depend is 2/week because of the frequent incidence of neutropenia in this group.
  3. After long-term or repeated therapy, resistant viruses might develop in immunocompromised sufferers.
  4. Pomocné látky: Watch out for sodium within the infusion liquid in the case of a low-sodium food plan.

Zovirax Side Effects

Spolu se svými potřebnými účinky může lék způsobit některé nežádoucí účinky. I když se nemusí vyskytnout všechny tyto nežádoucí účinky, pokud se vyskytnou, mohou vyžadovat lékařskou pomoc. Okamžitě se poraďte se svým lékařem, pokud se objeví některý z následujících nežádoucích účinků:

  • nevolnost
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  • závrať
  • únava
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  • póry a kožní vyrážka
  • svědění
  • urticaria, and improvement in diffuse hair loss.
  • angioedém
  • anafylaxe
  • dyspnoe
  • křeče
  • encephalopathy
  • kóma
  • třes
  • ataxie
  • dysarthria

The next additional event that happens after i.v. administration is hypotension. Diaphoresis. Fast improvement in blood urea and creatinine ranges (particularly in instances of dehydration, poor renal function and/or too speedy infusion) is in all probability attributable to precipitation of aciclovir crystals within the renal tubules and, in uncommon instances, results in acute renal failure. extreme native irritation and thrombophlebitis on the injection site, resulting in ulcerations on extravasation.

Zřeknutí se odpovědnosti

Information concerning psychotic disorders, included within the review of Zovirax, is used for the informative features exclusively and should not be thought of as an alternative to licenced healthcare or referral of the well-being treatment distributor.

 

Is Prohlášení o odpovědnosti

Tento web není spojen s žádnými značkami. Vlastní všechny značky, loga a obrázky. Obsah těchto webových stránek je pouze pro informační účely a není určen jako lékařská rada, diagnóza nebo léčba. Máte-li dotazy ohledně zdravotního problému, poraďte se s lékařem. Neodmítejte lékařskou radu ani neodkládejte její získání kvůli této webové stránce.

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Často kladené otázky

  1. What is Zovirax?

    Herpes infections of the skin, lip, and genitals can be treated with the antiviral medication Zovirax, as can herpes zoster and chickenpox. Zovirax is effective in preventing the replication of viruses, but it is not effective in treating illnesses that are caused by viruses, such as the common cold.

  2. Co dělat, když vynecháte dávku?

    If you forget to take your Zovirax pill, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the dose you missed and go back to your regular dosing schedule. Do not double doses.

  3. What if u take too much Zovirax?

    In the event of an overdose, contact your primary care physician or the emergency room of the hospital closest to you. It's possible that you need urgent medical care. You could also try getting in touch with the hospital's poison management team in your area.

  4. How to store Zovirax?

    Uchovávejte předmět na tmavém a suchém místě při teplotě mezi 59 a 77 stupni Fahrenheita (15 až 25 stupňů Celsia) a mimo dosah dětí a zvířat.

  5. What Should I Avoid While Taking Zovirax?

    Drowsiness of a noticeable degree is possible. avoid alcoholic drinks It is important to exercise caution when driving a motor vehicle or operating machinery because alcohol, sedatives, and tranquilizers can cause or worsen drowsiness, and excitability can occur, especially in children.

  6. What are the side effects of Zovirax?

    In the case of an allergic reaction, symptoms may include hives, difficulty breathing, and swelling of the face, lips, tongue, and throat. In addition, the likelihood of experiencing pain in the lower back, urinating less frequently than usual or not at all, easily bruising or bleeding, and unusual weakness increases significantly.

  7. Jaké jsou kontraindikace?

    Patients diagnosed with a kidney disorder are not permitted to take Zovirax. In addition, the use of Zovirax should be avoided in patients who have a hypersensitivity to Zovirax, Acyclovir, or drugs with similar effects.


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