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Značka (y): Omez

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Omez Drug Recommendation

For the therapy of endoscopically confirmed esophagitis, proton pump inhibitors are the usual therapy, with Omez being the popular alternative. Proton pump inhibitors have been proven to be simpler than H2-receptor antagonists and antacids. In instances of esophagitis grade C and D, the use is lifelong.

The therapy of first-episode abdomen complaints, practical abdomen complaints and gastroesophageal reflux illness consists of step by step rising the diploma of acid inhibition with an antacid, an H2 -receptor antagonist and a proton pump inhibitor, respectively. If the impact is passable, the treatment is step by step stopped. With an antacid, desire is given to the mix of algeldrate/magnesium hydroxide (works sooner and longer), with an H-receptor antagonist to famotidine and with a proton pump inhibitor to Omez; this in reference to the broader applicability and worth.2

For the therapy of abdomen complaints on account of NSAID use, a proton pump inhibitor, ideally Omez, needs to be thought of. The therapy of gastric complaints attributable to different treatment consists of step by step rising the diploma of acid inhibition with an antacid, an H 2-receptor antagonist and a proton pump inhibitor, respectively.

Gastric safety when utilizing NSAIDs and low-dose salicylates is indicated in sufferers with threat elements for gastric harm (see gastric safety#ideas). A proton pump inhibitor, ideally Omez, needs to be thought of as a abdomen protector.

Peptic ulcers brought on by H. pylori are handled with the mix of a proton pump inhibitor (Omez) and two antibiotics (amoxicillin and clarithromycin). If eradication is profitable, probably after a second therapy, the danger of recurrence is low.

Co byste měli před použitím tohoto léku prodiskutovat se svým lékařem

  • Být těhotná
    • Teratogeneze: No proof of harmfulness.
    • Doporučení: Can be utilized safely.

  • Laktace
    • Přechod v mateřském mléce: Sure, to a minor extent.
    • Farmakologický dopad: Proton pump inhibitors are unstable within the acidic setting of the toddler abdomen and are more likely to be quickly damaged down.

Kontraindikace: Hypersensitivity to substituted benzimidazoles (equivalent to different proton pump inhibitors, domperidone, albendazole).

Omez Drug Interactions

Omez is a reasonable CYP2C19 inhibitor and is metabolized by CYP2C19 and to a lesser extent by CYP3A4. Brokers that induce CYP2C19 and/or CYP3A4, equivalent to rifampicin and St. John’s wort, might lower the blood degree of Omez. Robust inhibitors of CYP2C19 and/or CYP3A4 (e.g. clarithromycin, voriconazole) might improve plasma ranges of Omez. When utilizing voriconazole or clarithromycin, dosage adjustment of Omez could also be obligatory in case of extreme hepatic impairment and long-term therapy.

Omez might reasonably inhibit the oxidative metabolism of some substances by inhibiting CYP2C19. Thus, the elimination of acenocoumarol, diazepam and phenytoin could also be delayed, adjustment of the dosage of acenocoumarol and phenytoin (particularly with larger doses of Omez) might then be obligatory. Through the first two weeks and after discontinuation of Omez, monitor phenytoin ranges.

The absorption of digoxin might improve together with Omez; particularly with excessive doses of Omez within the aged, digoxin ranges needs to be checked extra ceaselessly. Omez might scale back oral absorption of vitamin B 12(cyanocobalamin) attributable to hypo- or achlorhydria.

Proton pump inhibitors together with (particularly excessive dose) methotrexate can improve the degrees of methotrexate and extend its period of motion; this may result in poisonous signs of methotrexate; take into account quickly stopping the proton pump inhibitor when utilizing excessive dose methotrexate.

Omez Dosage

  1. Duodenal ulcer
    • Dospělí (včetně věku)
      • Beginning dose: 20 mg 1×/day for two weeks, lengthen for two extra weeks if obligatory; for persistent ulcers 40 mg 1×/day for 4 weeks.
      • Upkeep therapy to stop relapses: 20 mg 1×/day, generally 10 mg 1×/day is adequate, if obligatory improve to 40 mg 1×/day.

  2. Ventriculus ulcer
    • Dospělí (včetně věku)
      • Beginning dose: 20 mg 1×/day for 4 weeks, lengthen for an additional 4 weeks if obligatory; for persistent ulcers 40 mg 1×/day for 8 weeks.
      • Upkeep therapy to stop relapses: 20 mg 1×/day, improve to 40 mg 1×/day if obligatory.

  3. Reflux esophagitis
    • Dospělí (včetně věku)
      • Beginning dose: 20 mg 1×/day for 4 weeks, lengthen by 4 extra weeks if obligatory; in case of extreme reflux esophagitis 40 mg 1×/day for 8 weeks.
      • Upkeep therapy to stop relapses: 10 mg 1×/day, if obligatory 20-40 mg 1×/day.
    • Kids 1 to 12 months
      • 1 mg/kg physique weight 1×/day, for 4-8 weeks.
    • Kids > 1 12 months
      • Physique weight:
        • 10-20 kg: 10 mg 1×/day, if obligatory max. 20 mg 1×/day for 4-8 weeks;
        • > 20 kg: 20 mg 1×/day, if obligatory max. 40 mg 1×/day for 4-8 weeks.
  4. Signs of gastro-oesophageal reflux
    • Dospělí (včetně věku)
      • Beginning dose: 10-20 mg 1×/day. If there isn’t a clear enchancment in signs after 4 weeks, additional investigation is really useful. S
      • Self-care: 20 mg 1×/day within the morning till the signs have disappeared (often for 7 days), use for a most of 14 consecutive days with out consulting a health care provider.
    • Kids > 1 12 months
      • Physique weight:
        • 10-20 kg: 10 mg 1×/day, if obligatory max. 20 mg 1×/day;
        • > 20 kg: 20 mg 1×/day, if obligatory max. 40 mg 1×/day for 2-4 weeks.
          If the signs haven’t disappeared by then, additional investigations are obligatory.
    • Kids 1 to 12 months
      • 1 mg/kg physique weight 1×/day, for 2-4 weeks. If signs persist after 2-4 weeks, the affected person needs to be investigated additional.

  5. NSAID-induced ulcers and erosions
    • Dospělí (včetně věku)
      • Beginning dose: 20 mg 1×/day for 4 weeks; lengthen by 4 extra weeks if obligatory.
      • Upkeep therapy (for prevention of NSAID-related ulcers, erosions or dyspepsia in high-risk sufferers): 20 mg 1×/day.

  6. Eradication of Helicobacter pylori
    • Dospělí (včetně věku)
      • For ulcerous peptic ulcers:
        • Triple remedy, relying on resistance:
          • 2×/day for 1 week: 20 mg Omez together with 1000 mg amoxicillin and 500 mg clarithromycin;
          • 2×/day for 1 week: 20 mg Omez together with 250 mg clarithromycin and 500 mg metronidazole;
          • 1 week: 40 mg Omez 1×/day together with 500 mg amoxicillin and 500 mg metronidazole, each 3×/day. If obligatory, repeat therapy if the affected person remains to be H. pylori optimistic after completion of the course.
    • Kids > 4 years
      • Within the case of duodenal ulcers: Triple remedy, relying on resistance, e.g.
        • physique weight 15-30 kg: 2×/day throughout 1 week:
          • Omez 10 mg
          • amoxicillin 25 mg/kg
          • clarithromycin 7.5 mg/kg
        • physique weight 31-40 kg: 2×/day throughout 1 week:
          • Omez 20 mg
          • amoxicillin 750 mg
          • clarithromycin 7.5 mg/kg
        • physique weight > 40 kg: 2×/day throughout 1 week:
          • Omez 20 mg
          • amoxicillin 1000 mg
          • clarithromycin 500 mg

  7. Zollinger-Ellisonův syndrom
    • Dospělí (včetně věku)
      • Really helpful beginning dose 60 mg 1×/day, then modify individually, usually 20-120 mg day by day and proceed therapy so long as clinically obligatory. Dosages above 80 mg per day to be taken in 2 doses.

Porucha funkce jater: a day by day dose of 10-20 mg could also be adequate. For the dosage recommendation from Stichting Well being Base in case of liver cirrhosis, see the webpage proton pump inhibitors on

Renal impairment: a dose adjustment shouldn’t be obligatory.

Proper Usage of Omez

  • The oral suspension (2 mg/ml) is appropriate for doses ≤ 15 mg. The oral suspension needs to be taken on an empty abdomen, no less than half-hour earlier than meals. The suspension might be administered by way of a nasogastric (NG) or percutaneous endoscopic gastrostomy (PEG) tube.
  • Take the capsules and tablets within the morning on an empty (sober) abdomen with out chewing, with a glass of water. Omez shouldn’t be immune to acid and is run in a gastro-resistant coating.
  • In case of swallowing issues, the capsules might be opened and the granules might be taken (with out grinding or chewing) with a barely acidic liquid (e.g. fruit juice or apple sauce). Alternatively, the capsules could also be sucked, then the granules swallowed, with out chewing, with half a glass of water.
  • The tablets could also be damaged and disintegrated in water or barely acidic liquid. Don’t use milk or carbonated water and take the answer inside half-hour after stirring nicely, rinse with water and drink it.

Omez Precautions

Proton pump inhibitors are related to very uncommon instances of subacute cutaneous lupus erythematodes (SCLE). If lesions happen, particularly on sun-exposed pores and skin and accompanying joint ache, medical consideration needs to be sought instantly and therapy discontinuation thought of. The danger of SCLE after therapy with a proton pump inhibitor could also be elevated by means of one other proton pump inhibitor.

In case of alarm signs (equivalent to extreme unintentional weight reduction, frequent vomiting, dysphagia, haematoma or melena) exclude a malignancy. Omez might masks signs of gastric carcinoma.

Extreme hypomagnesaemia might happen with extended use of proton pump inhibitors. Look ahead to indicators of hypomagnesia equivalent to:

  • tetany
  • únava
  • delirium
  • křeče
  • závrať
  • ventricular arrhythmias

Take into account common monitoring of magnesium ranges when mixed with digoxin or different medicine that will decrease magnesium ranges (equivalent to diuretics). Proton pump inhibitors might improve the danger of fracture, particularly within the aged or within the presence of different threat elements.

Briefly discontinue therapy with Omez for no less than 5 days for chromogranin A (CgA) measurements. If CgA and gastrin ranges haven’t normalised inside 5 days of discontinuation, repeat CgA measurement 14 days after discontinuation of Omez.

Cirpo vedlejší účinky

  • nevolnost
  • zvracení
  • průjem
  • zácpa
  • stomach ache and flatulence
  • benign fundic-gland polyps
  • Bolest hlavy
  • itching, rash, dermatitis, urticaria
  • Peripheral oedema, malaise

Different reported signs are: innocent discolouration of abdomen contents on vomiting, subacute cutaneous lupus erythematodes (SCLE). Microscopic colitis. Hypomagnesia which in extreme instances might result in hypocalcemia or hypokalemia.

Zřeknutí se odpovědnosti

Information concerning psychotic disorders, included within the review of Omez, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


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Často kladené otázky

  • What is Omez?

    This medicine is a proton pump inhibitor (PPI) used to treat ulcers, heartburn, gastroesophageal reflux, erosive esophagitis, or Zollinger-Ellison syndrome and also ulcers generated by long-term use of non-steroidal anti-inflammatory drugs (NSAIDs). To treat ulcers caused by bacterial infections this medicine may be used in combination with antibiotics such as amoxicillin or clarithromycin.

  • Co dělat, když vynecháte dávku?

    If you miss a dose of Omez, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  • What if u take too much Omez?

    Pokud dojde k předávkování, pojmenujte svého lékaře nebo zavolejte do nejbližší nemocnice. Možná máte naléhavou lékařskou péči. Můžete se také obrátit na správu jedů ve vaší místní nemocnici.

  • How to store Omez?

    Skladujte při pokojové teplotě mezi 15–25 ° C mimo světlo a vlhkost, děti a domácí zvířata. 

  • What Should I Avoid While Taking Omez?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Omez. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  • What are the side effects of Omez?

    Adverse reactions that may disappear during treatment include headache, constipation, cough, dizziness, or rash. 

  • Jaké jsou kontraindikace?


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