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Active Ingredient: Allopurinol
Brand(s): Zyloprim

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DosageQuantityPriceCheck product
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100 mg180 pills€ 177,00
300 mg30 pills€ 95,00
300 mg60 pills€ 129,00
300 mg90 pills€ 147,00
300 mg120 pills€ 165,00
300 mg180 pills€ 189,00

What is Allopurinol?

Allopurinol oral pill is a prescription drug that’s out there because the brand-name medication Zyloprim and Lopurin. It’s additionally out there as a generic drug. Generic medication normally price much less. In some instances, they is probably not out there in each energy or type because the brand-name model. Allopurinol additionally is available in an intravenous (IV) type, which is just given by a healthcare supplier. Allopurinol could also be used as a part of mixture remedy. This means you could have to take it with different medicines.

What allopurinol is used for?

Allopurinol is a medicine used to lower levels of uric acid in your blood. If you produce too much uric acid or your kidneys do not filter enough out, it can build up and cause tiny, sharp crystals to form in and around your joints. Allopurinol is used to treat gout and kidney stones.

How to use Allopurinol?

This dosage data is for allopurinol oral tablets. All potential dosages and drug kinds is probably not included right here. Your dosage, drug type, and the way typically you’re taking the drug will rely upon:

  • your age
  • the situation being handled
  • how extreme your situation is
  • different medical situations you’ve got
  • the way you react to the primary dose

Dosage Allopurinol

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Adult dosage (ages 18–64 years)

  • Typical beginning dose: 100 mg per day
  • Dose changes: Your physician might enhance your dose by 100 mg per week till you’ve reached the specified degree of serum uric acid.
  • Usual dose:
    • Mild gout: 200–300 mg per day
    • Moderate to extreme gout: 400–600 mg per day
  • Maximum dose: 800 mg per day taken in divided doses

Child dosage (ages 0–17 years)

This medicine hasn’t been studied and shouldn’t be utilized in individuals youthful than 18 years for this situation.

Senior dosage (ages 65 years and older)

The kidneys of older adults might not work in addition to they used to. This may cause your physique to course of medication extra slowly. As a end result, extra of a drug stays in your physique for an extended time. This raises your threat of unwanted side effects. Your physician might begin you on a lowered dose or a unique dosing schedule. This will help hold ranges of this drug from increase an excessive amount of in your physique.

Dosage for elevated serum uric acid ranges resulting from cancers remedies

  • Adult dosage (ages 18–64 years): 600–800 mg per day for two or 3 days.
  • Child dosage (ages 11–17 years): 600–800 mg per day for two or 3 days
  • Child dosage (ages 6–10 years): 300 mg per day. Your physician will regulate your dose as wanted primarily based in your serum uric acid degree.
  • Child dosage (ages 0–5 years): 150 mg per day. Your physician will regulate your baby’s dose as wanted primarily based in your serum uric acid degree.
  • Senior dosage (ages 65 years and older): The kidneys of older adults might not work in addition to they used to. This may cause your physique to course of medication extra slowly. As a end result, extra of a drug stays in your physique for an extended time. This raises your threat of unwanted side effects.

Your physician might begin you on a lowered dose or a unique dosing schedule. This will help hold ranges of this drug from increase an excessive amount of in your physique.

Allopurinol Dosage for recurrent kidney stones

  • Adult dosage (ages 18–64 years): Typical dosage is 200–300 mg per day taken in a single or divided doses.
  • Child dosage (ages 0–17 years): This medicine hasn’t been studied and shouldn’t be utilized in individuals youthful than 18 years for this situation.
  • Senior dosage (ages 65 years and older): The kidneys of older adults might not work in addition to they used to. This may cause your physique to course of medication extra slowly. As a end result, extra of a drug stays in your physique for an extended time. This raises your threat of unwanted side effects.
  • Your physician might begin you on a lowered dose or a unique dosing schedule. This will help hold ranges of this drug from increase an excessive amount of in your physique.

Should I take Allopurinol in the morning or at night?

It will also help you remember when to take it. Allopurinol is usually taken once daily. However, if your dose is more than 300 mg, your doctor may advise you to take your medicine twice a day. Then, it should be taken morning and night, after breakfast and dinner.

Can you take Allopurinol with blood pressure tablets?

Allopurinol does not produce additional antihypertensive effects in patients with treated arterial hypertension. Allopurinol increases aortic compliance independently of ACE-I or thiazide-based, antihypertensive therapy.

When can I stop taking Allopurinol?

Allopurinol should not be stopped during acute flares of gout. Stopping allopurinol during an acute flare means therapeutic effect is lost and the urate level will rise. In addition, there is a real risk of the allopurinol not being recommenced as well as precipitating another flare when it is recommenced.

Overdose

You might have harmful ranges of the drug in your physique. Symptoms can embody:

  • pores and skin rash
  • diarrhea
  • nausea
  • adjustments in your liver perform check outcomes
  • gout flare-up (when you’ve got gout)

If you suppose you’ve taken an excessive amount of of this drug, name your physician or native poison management middle. If your signs are extreme, name 911 or go to the closest emergency room straight away.

Missed Dose

Take your dose as quickly as you bear in mind. But in case you bear in mind only a few hours earlier than your subsequent scheduled dose, take just one dose. Never attempt to catch up by taking two doses directly. This might end in harmful unwanted side effects.

Do I have to take allopurinol forever?

Treatment with allopurinol is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by a doctor. There are a number of lifestyle changes that you can make to help reduce the risk of having a gout attack.

Allopurinol Interactions

Drug interactions might change how your medicines work or enhance your threat for severe unwanted side effects. This doc doesn’t comprise all potential drug interactions. Keep a listing of all of the merchandise you employ (corresponding to prescription/nonprescription medication and natural merchandise) and share it along with your physician and pharmacist. Do not begin, cease, or change the dosage of any medicines with out your physician’s approval. Some merchandise which will work together with this drug are: “blood thinners” (e.g., warfarin), capecitabine, didanosine.

Is there an alternative to Allopurinol?

Febuxostat is a urate-lowering therapy that is now TGA-approved and PBS-listed for long-term treatment of certain patients with chronic gout. It can be prescribed by GPs and has become the usual first alternative for allopurinol-intolerant patients, replacing uricosuric therapies.

Allopurinol Side Effects

Allopurinol oral pill might trigger drowsiness. You shouldn’t drive, use equipment, or do different duties that require alertness till you understand how allopurinol impacts you. It also can trigger different unwanted side effects.

More frequent unwanted side effects

The extra frequent unwanted side effects of allopurinol oral pill can embody:

  • pores and skin rash
  • diarrhea
  • nausea
  • adjustments in your liver perform check outcomes
  • gout flare-up (when you’ve got gout)

If you develop a pores and skin rash, discuss your physician straight away. You mustn’t proceed taking allopurinol in case you develop a rash. Other delicate unwanted side effects might go away inside just a few days or a few weeks. If they’re extra extreme or don’t go away, discuss to your physician or pharmacist.

Other possible side effects

Call your physician straight away when you’ve got severe unwanted side effects. Call 911 in case your signs really feel life-threatening or in case you suppose you’re having a medical emergency. Serious unwanted side effects and their signs can embody the next:

  • Severe pores and skin rash. Symptoms can embody:
    • itchy hives (raised bumps in your pores and skin)
    • crimson or purple-colored spots in your pores and skin
    • scaly pores and skin
    • fever
    • chills
    • hassle respiratory
    • swelling of your face or throat
  • Liver damage. Symptoms can embody:
    • tiredness
    • lack of urge for food
    • weight reduction
    • proper higher belly space ache or discomfort
    • jaundice (dark-colored urine or yellowing of your pores and skin or the whites of your eyes)

What does Allopurinol do to your kidneys?

Allopurinol decreases C-reactive protein and slows down the progression of renal disease in patients with chronic kidney disease. In addition, allopurinol reduces cardiovascular and hospitalization risk in these subjects.

Does Allopurinol raise blood pressure?

Allopurinol is associated with a small but significant reduction in BP. This effect can be potentially exploited to aid in controlling BP in hypertensive patients with hyperuricemia.

Does Allopurinol make you pee?

This drug can cause drowsiness. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how it affects you. Fluid intake: You should drink at least 3.4 liters (14 cups) of fluids each day. This will help you urinate at least 2 liters (2 quarts) per day.

Can Allopurinol cause weight gain?

Can allopurinol cause weight gain? Weight loss is more likely with allopurinol than weight gain. With allopurinol, patients experience weight loss, nausea, and a loss of appetite. Acute gout attacks, diarrhea, nausea, and skin rash are all possible side effects of allopurinol.

Can Allopurinol cause neuropathy?

A patient experienced an axonomyelinic peripheral neuropathy during a long-term allopurinol treatment. The symptoms and signs regressed after drug withdrawal, and the nerve conduction velocities and distal latencies improved. The incidence of allopurinol-induced peripheral neuropathy is very low.

Allopurinol Precautions

  • Before taking allopurinol, inform your physician or pharmacist in case you are allergic to it; or when you’ve got had a extreme response to it; or when you’ve got another allergic reactions. This product might comprise inactive substances, which might trigger allergic reactions or different issues. Talk to your pharmacist for extra particulars.
  • Before utilizing this medicine, inform your physician or pharmacist your medical historical past, particularly of: liver illness, kidney illness, diabetes, hypertension (hypertension), uncommon diets (e.g., fasting).
  • This drug might make you drowsy. Alcohol or marijuana (hashish) could make you extra drowsy. Do not drive, use equipment, or do something that wants alertness till you are able to do it safely. Alcohol may additionally lower the effectiveness of this drug. Limit alcoholic drinks. Talk to your physician in case you are utilizing marijuana (hashish).
  • Kidney perform declines as you get older. This medicine is eliminated by the kidneys. Therefore, older adults could also be at larger threat for unwanted side effects whereas utilizing this drug.
  • During being pregnant, this medicine needs to be used solely when clearly wanted. Discuss the dangers and advantages along with your physician.

Allopurinol Storage

Store at room temperature away from mild and moisture. Do not retailer within the lavatory. Keep all medicines away from youngsters and pets. Do not flush medicines down the bathroom or pour them right into a drain until instructed to take action. Properly discard this product when it’s expired or now not wanted. Consult your pharmacist or native waste disposal firm.

 

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Frequently asked questions

  • What is Allopurinol?

    Allopurinol oral tablet is a prescription drug that’s available as the brand-name drugs Zyloprim and Lopurin. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

  • What if u take too much Allopurinol?

    If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at Your local hospital.

  • What to do if you miss a dose?

    If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose. Take your next dose at a regular time. Do not double the dose to catch up.

  • What is the normal dosage to use?

     Take it orally once daily, probably after a meal. When you take Allopurinol you have to drink eight glasses of any liquids per day. Commonly use a dose of Allopurinol is 200 to 300 milligrams taken once daily.

  • How to store Allopurinol?

    Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. Do not use after expiration term.

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