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Active Ingredient: Amantadine
Brand(s): Symmetrel

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What is Amantadine?

Amantadine is an irregular antipsychotic medicine. blocks dopamine receptors in the CNS as well as conflicts dopamine buttons in basic gangliya as well as in limbic a component of the neoncephalon. It is taken for hypersensitivity, disorders of the hemopoietic system (along with anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

What is the action of amantadine?

Amantadine interferes with the release of infectious viral nucleic acid into the host cell through interaction with the transmembrane domain of the M2 protein of the virus. It also appears to prevent virus assembly during replication in some cases.

Why is amantadine used in Parkinson disease?

Immediate-release Amantadine is a mild agent that is used in early and advanced PD to help tremors. In recent years, amantadine has also been found useful in reducing dyskinesias that occur with dopamine medication.

Does amantadine give you energy?

Its anti-fatigue effects were first discovered when people with MS were treated for Asian flu and found that their energy levels were suddenly and significantly improved. However, due to widespread amantadine resistance, this drug has been phased out as an influenza treatment.

Symmetrel Drug Uses

Symmetrel is an antidyskinetic medication. It is used to deal with Parkinson’s illness (generally known as “paralysis agitans” or “shaking palsy”) and its signs, together with dyskinesia (sudden uncontrolled actions). It could also be given alone or together with different medicines (e.g., levodopa) for Parkinson’s illness. By enhancing muscle control and decreasing stiffness, this medication permits extra regular actions of the physique because the illness signs are decreased. Amantadine can also be used to deal with stiffness and shakiness attributable to certain medicines, which might be used to deal with nervous, psychological, and emotional situations.

Amantadine can also be an antiviral medication. It is used to stop or deal with certain influenza (flu) infections (sort A). It could also be given alone or along with flu photographs. Amantadine is not going to work for colds, different kinds of flu, or different viral infections.

What You Should Know Before Using This Medicine

  1. Renal disease: Because Amantadine is mainly excreted in the urine, it accumulates in the plasma and in the body when renal function declines. Thus, the dose of Amantadine should be reduced in patients with renal impairment and in individuals who are 65 years of age or older.
  2. Liver disease: Care should be exercised when administering Amantadine to patients with liver disease. Rare instances of reversible elevation of liver enzymes have been reported in patients receiving Amantadine , though a specific relationship between the drug and such changes has not been established.
  3. Melanoma: Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2-to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease or other factors, such as drugs used to treat Parkinson’s disease, is unclear.
  4. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Amantadine for any indication. Ideally, periodic skin examinations should be performed by appropriately qualified individuals (e.g., dermatologists).
  5. Nursing Mothers: Amantadine is excreted in human milk. Use is not recommended in nursing mothers.
  6. Pediatric Use: The safety and efficacy of Amantadine in newborn infants and infants below the age of 1 year have not been established.
  7. Usage in the Elderly: Because Amantadine is primarily excreted in the urine, it accumulates in the plasma and in the body when renal function declines. Thus, the dose of Amantadine should be reduced in patients with renal impairment and in individuals who are 65 years of age or older. The dose of Amantadine may need reduction in patients with congestive heart failure, peripheral edema, or orthostatic hypotension.

Amantadine Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different instances, two totally different medicines could also be used collectively, even when an interplay may happen. In these instances, your physician might need to change the dose or different precautions could also be mandatory. When you take this medication, it’s particularly vital that your healthcare professional know if you’re taking any of the medicines listed under. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the following medicines shouldn’t be really helpful. Your physician might decide to not deal with you with this medicine or change a number of the different medicines you are taking.

  • Potassium Chloride

Using this medication with any of the following medicines is normally not really helpful, but could also be required in some instances. If each medicine is prescribed collectively, your physician might change the dose or how often you utilise one or each of the medicines.

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming certain kinds of meals since interactions might happen. Using alcohol or tobacco with certain medicines may trigger conditions to happen. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Other Medical Problems Symmetrel

The presence of different medical issues might have an effect on the use of this medication. Make certain you inform your physician if you have any other medical issues, particularly:

  • Congestive coronary heart failure
  • Eczema
  • Epilepsy or seizures
  • Hypotension (low blood stress)
  • Liver illness
  • Neuroleptic malignant syndrome (NMS)
  • Peripheral edema (swelling of the fingers, ankles, or ft) 
  • Psychosis (psychological sickness)
  • Sleeping dysfunction
  • End-stage kidney illness
  • Glaucoma, angle-closure, untreated (narrow-angle glaucoma)
  • Kidney illness

Proper Usage of Amantadine

For sufferers taking amantadine for Parkinson’s illness or motion issues (together with dyskinesia) attributable to certain medicines used to deal with nervous, psychological, and emotional situations:

  • Take this medication precisely as directed by your physician. Do not take extra of it, don’t take it extra typically, and don’t take it for an extended time than your physician ordered.
  • This medication comes with a Medication Guide or affected person info leaflet. Read and observe these directions rigorously. Ask your physician if in case you have any questions.
  • Do not cease utilizing this medication all of a sudden with out asking your physician. You might have to slowly lower your dose earlier than stopping it utterly.
  • Improvement within the signs of Parkinson’s illness normally happens in about 2 days. However, in some sufferers, this medication should be taken for as much as 2 weeks earlier than the complete profit is seen.

For sufferers taking amantadine to stop or deal with flu infections:

  • Talk to your physician about the potential of getting a flu shot if in case you have not had one but.
  • This medication is greatest taken earlier than publicity or instantly after publicity to individuals who have the flu.
  • To assist preserve your self from getting the flu, preserve taking this medication for the complete time of remedy. Or if you have already got the flu, proceed taking this medication for the complete time of remedy even if you happen to start to really feel higher after just a few days. This will assist clear up your an infection utterly. If you cease taking this medication too quickly, your signs might return. This medication needs to be taken for at the very least 2 days after all of your flu signs have disappeared.
  • This medication works greatest when there’s a fixed quantity within the blood. To assist preserve the quantity fixed, don’t miss any doses. Also, it’s best to take the doses at evenly spaced instances at day and evening. For instance, if you’re to take two doses a day, the doses needs to be spaced about 12 hours aside. If this interferes along with your sleep or different each day actions, or if you happen to want assist in planning the very best instances to take your medication, examine along with your physician.
  • If you might be utilizing the oral liquid type of amantadine, use a marked measuring spoon, oral syringe, or medication cup to measure every dose appropriately. The common family teaspoon might not maintain the correct quantity of liquid.

Take Gocovri® extended-release capsule at bedtime. Swallow entire. Do not crush, break, or chew it. You may open and sprinkle the extended-release capsules on a teaspoonful of sentimental meals together with applesauce. Take the entire medication instantly without chewing. You may take this medication with or without meals.

Take Osmolex ERTM extended-release pill in the morning. Swallow entire. Do not crush, open, or chew it. Do not obtain the nasal flu vaccine (stay attenuated influenza vaccine) while taking this medication. Do not drink alcohol if you are using this medication.

How long can you take amantadine?

This medicine should be taken for at least 2 days after all your flu symptoms have disappeared. This medicine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times during the day and night.

Amantadine Dosage

The dose of this medication can be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following information consists solely of the common doses of this medication. If your dose is totally different, don’t change it until your physician tells you to.

The quantity of medication that you simply take will depend on the energy of the medication. The variety of doses you are taking every day, the time allowed between doses, and the length of time you are taking the medication depend on the medical drawback for which you might be utilising the medication.

  • For remedy of Parkinson’s illness or motion issues (together with dyskinesia):
    • For oral dosage varieties (extended-release capsules):
      • Adults: 137 milligrams (mg) as soon as a day at bedtime. Your physician might enhance your dose to 274 mg (two 137 mg capsules) as soon as a day at bedtime after one week.
      • Children: Use and dose should be decided by your physician.
    • For oral dosage varieties (extended-release tablets):
      • Adults: 129 milligrams (mg) as soon as a day within the morning. Your physician might enhance your dose every week to a most dose of 322 mg (one 129 mg pill and one 193 mg pill) as soon as a day taken within the morning.
      • Children: Use and dose should be decided by your physician.
    • For oral dosage varieties (liquid-filled capsules, syrup, and tablets):
      • Adults: 100 milligrams (mg) 2 instances a day. Your physician might alter your dose as wanted.
      • Older adults: At first, 100 milligrams (mg) as soon as a day as a single dose. Your physician might alter your dose as wanted.
      • Children: Use and dose should be decided by your physician.
  • For the remedy or prevention of flu:
    • For oral dosage varieties (capsules, syrup, and tablets):
      • Adults: 200 milligrams (mg) or 4 teaspoonfuls as soon as a day as a single dose.
      • Older adults: 100 milligrams (mg) as soon as a day as a single dose.
      • Children 9 to 12 years of age: 100 milligrams (mg) or 2 teaspoonfuls 2 instances a day.
      • Children 1 to 9 years of age: Dose is predicated on physique weight and should be decided by your physician. The ordinary dose is 4.4 to eight.8 milligrams (mg) per kilogram (kg) of physique weight per day. The dose is split evenly and given 2 instances a day. However, the dose is normally no more than 150 mg per day.
      • Children youthful than 1 12 months of age: Use and dose should be decided by your physician.

Missed Dosage

If you miss a dose of this medication, take it as soon as possible. However, if it is nearly time for your subsequent dose, skip the missed dose and return to your usual dosing schedule. Do not double the doses. If you miss a dose of amantidine, skip the missed dose and take your subsequent dose at your usual time. Do not take further medication to make up for a missed dose.

Do you need to wean off amantadine?

Amantadine should not be discontinued abruptly as it may cause NMS symptoms, and higher doses of amantadine need to be gradually tapered for 1 to 2 weeks before discontinuation.

How long before amantadine is out of your system?

The half-life was 17  4 hours (range: 10 to 25 hours). Across other studies, amantadine plasma half-life has averaged 16  6 hours (range: 9 to 31 hours) in 19 healthy volunteers.

Symmetrel Storage

  1. Store the medication in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
  2. Keep out of the attain of youngsters.
  3. Do not preserve outdated medication or medication now not wanted.
  4. Ask your healthcare skilled how you need to eliminate any medication you don’t use.

Amantadine Precautions

It is essential that your physician examine your progress at regular visits to see if the medication is working correctly and to permit adjustments in your dose. Blood and urine assessments could also be wanted to examine any side effects.

  • Amantadine might trigger some individuals to be agitated, irritable, or show different irregular behaviors. It may trigger some individuals to have suicidal ideas and tendencies or to change into extra depressed. Also inform your physician if in case you have sudden or robust emotions, comparable to feeling nervous, indignant, stressed, violent, or scared. If you, your little one, or your caregiver discover any of those antagonistic results, inform your physician or your kid’s physician instantly.
  • Some individuals who have used this medication had uncommon adjustments of their habits. Talk along with your physician instantly if you happen to begin having uncommon urges, comparable to playing urges, binge or compulsive consuming, compulsive buying, or sexual urges whereas utilizing this medication.
  • Drinking alcoholic drinks whereas taking this medication might trigger elevated uncomfortable side effects, comparable to circulation issues, dizziness, lightheadedness, fainting, or confusion. Do not drink alcoholic drinks if you are taking this medication.
  • This medication might trigger some individuals to change into dizzy, drowsy, or lightheaded, or to have blurred imaginative and prescient or bother concentrating. Do not drive or do anything that could possibly be harmful till you understand how this medication impacts you.

Amantadine Side Effects

Along with its wanted results, a medication might trigger some negative effects. Although not all of those uncomfortable side effects might happen, in the event that they do happen, they might want medical consideration.

Check with your physician immediately if any of the following uncomfortable side effects happen:

  • Bladder ache
  • bloody or cloudy urine
  • blurred imaginative and prescient
  • confusion
  • tough, burning, or painful urination
  • dizziness or lightheadedness
  • fainting
  • falls
  • frequent urge to urinate
  • decrease again or facet ache
  • seeing, listening to, or feeling issues that aren’t there
  • swelling of the fingers, ft, or decrease legs

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify them with your healthcare professional. Call your physician for a medical recommendation about any negative effects.

Does amantadine affect blood pressure?

Amantadine antagonises the blood pressure responses evoked by electrical stimulation of the central and peripheral ends of the vagus. Blood pressure responses to sympathetic stimulation are also attenuated. These results could be explained on the basis of a possible effect on autonomic ganglia.

Is Amantadine an antidepressant?

Amantadine blocks N-methyl-D-aspartate (NMDA) receptors and has dopaminergic and noradrenergic action, a neurochemical profile that suggests its potential as an antidepressant drug.

Is Amantadine a dopamine agonist?

Amantadine, a dopamine agonist, is reported to act by releasing dopamine from the dopaminergic nerve terminals as an anti-Parkinsonian drug. In the present behavioural study in the rat, molindone-induced catalepsy and ptosis, which are dopamine-dependent behaviours, are reversed by amantadine.

How does amantadine increase dopamine?

Amantadine increases the extracellular dopamine levels in the striatum by re-uptake inhibition and by N-methyl-D-aspartate antagonism.

Can you drink while taking amantadine?

Do not drink alcoholic beverages while you are taking this medicine. This medicine may cause some people to become dizzy, drowsy, or lightheaded, or to have blurred vision or trouble concentrating. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

How does amantadine work on Covid?

Amantadine, by its lipophilic nature, is able to cross the endosome membrane and interrupt the release of the virion into the cell. Similarly, amantadine may enter the E-channel of the coronavirus, preventing the release of the viral nucleus into the cell.

Can humans take amantadine?

It has not been confirmed that amantadine is safe and effective for use in people younger than 18 years. The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, an increased amount of a drug stays in your body for a longer time.

Disclaimer

Information concerning psychotic disorders, included within the review of Amantadine, is used for the informative features exclusively and should not be thought of as an alternative to licenced healthcare or referral of the well-being treatment distributor.

 

⚠Disclaimer of liability

Pfizer is not affiliated with this site. The brand name, logos, and images used are the property of Pfizer. The content of this site is for informational purposes only. We do not supply, market, or ship medicines ourselves and refer you to reputable online stores on the Internet. Always consult a physician when using medicines.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price for many people, and you can easily and legally obtain this powerful medicine.

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Frequently asked questions

  1. What is Amantadine Symmetrel?

    Amantadine is an antiviral medication that is used to prevent or treat certain influenza infections. Symmetrel is a drug that is used to treat Parkinson’s disease and “Parkinson-like” symptoms, including shaking and stiffness. Amantadine is an antiviral medication that is used to prevent or treat certain influenza infections.

  2. What to do if you miss a dose?

    If you forget to take a dose of amantadine, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the dose you missed and go back to your regular dosing schedule. You should never double your doses.

  3. What if u take too much Symmetrel?

    In the event of an overdose, contact your primary care physician or the emergency room of the hospital closest to you; you may require immediate medical attention. If necessary, you may also get in touch with the hospital’s poison control centre.

  4. How to store Amantadine?

    Keep the item in a dark, dry place at a temperature between 59 and 77 degrees Fahrenheit (15 and 25 degrees Celsius) and out of the reach of children and animals.

  5. What Should I Avoid While Taking Amantadine?

    While you are taking Symmetrel, you should avoid drinking alcohol or using illegal drugs because doing so could reduce the benefits of the medication (for example, it could make your confusion even worse) and increase the adverse effects (for example, it could make you more sedated).

  6. What are the side effects of Amantadine Symmetrel?

    A feeling of shortness of breath, even with mild exertion, swelling, rapid weight gain, and feelings of depression, agitation, or aggression are among the most likely adverse reactions that could occur.

  7. What are the Contraindication?

    Contraindicated in the case of individuals who are prone to convulsions, as well as in cases where a person’s medical history includes gastric ulceration or severe renal disease, as well as when someone is pregnant.

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