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What is Endep

Endep is an irregular antipsychotic medicine. Blocks dopamine receptors in the CNS and also competes with the dopamine button in the basal ganglia and the limbic system, both of which are components of the neonatal brain. It is used to treat hypersensitivity, hemopoietic system disorders (including anamnesis), alcoholic and harmful psychoses, myasthenia, and comas.

Endep Drug Uses

  • Endep is used to deal with despair.
  • Endep 10 mg and Endep 25 mg tablets can be utilized at any stage within the remedy of despair. Nevertheless, the very best energy Endep 50 mg, is permitted just for the upkeep remedy of despair (after your signs have improved).
  • Endep belongs to a bunch of medicines referred to as tricyclic antidepressants (TCAs). TCA medicines work by correcting the imbalance of sure chemical compounds within the mind. These chemical compounds, referred to as amines, are concerned in controlling temper. By correcting this imbalance, TCAs might help relieve the signs of despair.
  • Endep will also be used to deal with bed-wetting, offered that there isn’t any bodily trigger for the issue (eg. issues with the bladder).

Ask your physician if you have any questions about why Endep has been prescribed for you. Your physician could have prescribed Endep for an additional purpose.

Endep is not approved for use in children and adolescents under the age of 18 for the treatment of depression. The protected use and effectiveness of Endep in treating the above situation for this age group have not been established.

What Should You Discuss To Your Doctor Before Using This Medicine

When you could not take it

  • Don’t take Endep if you’re allergic to medicines containing Endep.
    • A few of the signs of an allergic response could embrace pores and skin rash, itching or hives; swelling of the face or tongue which can trigger problem swallowing or respiration; elevated sensitivity of the pores and skin to the solar.
  • Don’t take Endep in case you have just lately had a coronary heart assault.
    • Taking Endep might make your situation worse.
  • Don’t take Endep if you’re taking, or have taken throughout the final 14 days one other medication for despair referred to as a monoamine oxidase inhibitor (MAOI).
    • Taking Endep with a MAOI or taking it too quickly after stopping a MAOI could trigger a critical response with a sudden improve in physique temperature, extraordinarily hypertension and extreme convulsions. Your physician will inform you when it’s protected to begin taking Endep after stopping the MAOI.
  • Ask your physician or pharmacist if you’re not sure if you’re taking, or have been taking a MAOI.
    • MAOIs are medicines used to deal with despair and signs of Parkinson’s illness. Examples of MAOIs are phenelzine (Nardil), tranylcypromine (Parnate), moclobemide (eg. Aurorix, Arima) and selegiline (Eldepryl, Selgene).
  • Don’t take Endep if you’re taking cisapride (Prepulsid), a medication used to deal with abdomen reflux.
    • Combining Endep with cisapride could trigger critical negative effects akin to an irregular coronary heart rhythm.
  • Don’t take Endep if you’re breastfeeding.
    • Endep passes into breast milk and should hurt your child.
  • Don’t take Endep if the expiry date (EXP) printed on the pack has handed.
    • In case you take this medication after the expiry date has handed, it might not work as nicely.
  • Don’t take Endep if the packaging reveals indicators of tampering or the tablets don’t look fairly proper.
  • If you’re unsure whether or not it’s best to begin taking this medication, discuss to your physician.

Before taking this medicine

  • Inform your physician if you’re allergic to some other medicines, meals, dyes or preservatives.
  • Inform your physician if you’re pregnant or plan to grow to be pregnant.
    • There have been reviews of some infants experiencing problems instantly after supply. Your physician will talk about the potential dangers and advantages of taking Endep throughout being pregnant.
  • Inform your physician in case you have, or have had, some other medical circumstances, particularly the next:
    • coronary heart or blood vessel issues
    • liver issues
    • glaucoma, a situation characterised by an elevated stress within the eye
    • urinary issues akin to problem in passing urine
    • thyroid issues
    • seizures or suits
    • any psychological sickness aside from despair, for instance schizophrenia.
  • Inform your physician if you happen to plan to bear any sort of surgical procedure or if you’re present process electroshock remedy.

If you haven’t told your doctor about any of the above, do so as soon as you start taking Endep.

Endep Drug Interactions

Don’t take Endep if you’re taking

  • cisapride (Prepulsid), a medication used to deal with abdomen reflux
  • any monoamine oxidase inhibitor (MAOI) akin to:
  • phenelzine (Nardil) and tranylcypromine (Parnate), moclobemide (eg. Aurorix, Arima), used to deal with despair
  • selegiline (Eldepryl, Selgene), used to deal with signs of Parkinson’s illness.

Wait at least 14 days after stopping your MAOI before starting Endep.

Inform your doctor if you are taking any other medications, including any that you obtained without a prescription from a pharmacy, grocery store, or health food store.

Inform your physician if you’re taking or have recently taken some other medicines akin to valproic acid.

Some medicines could also be affected by Endep or have an effect on how well it works. These embrace:

  • selective serotonin reuptake inhibitors (SSRIs), a bunch of medicines used to deal with despair and different psychological diseases, akin to:
    • fluoxetine (eg. Prozac, Lovan)
    • sertraline (eg. Zoloft)
    • paroxetine (eg. Aropax, Paxtine)
  • some medicines used to deal with hypertension
  • anticholinergics, present in some medicines used to alleviate:
    • abdomen cramps
    • journey illness
    • hayfever and allergic reactions
    • cough and colds
  • medicines used to deal with psychological problems akin to schizophrenia
  • quinidine (Kinidin) and flecainide (Tambocor, Flecatab), medicines used to regulate an irregular coronary heart beat
  • cimetidine (eg. Tagamet, Magicul), a medication used to deal with reflux and ulcers
  • sleeping tablets/sedatives, anti-anxiety medicines
  • medicines for epilepsy
  • thyroid medicines
  • disulfiram (eg. Antabuse), a medication used to discourage alcohol consumption
  • tramadol (eg. Tramal), a medication used to alleviate ache.

Your physician can tell you what to do if you’re taking any of those medicines.

If you’re unsure whether or not you take any of those medicines, examine them together with your physician or pharmacist.

  • Your physician and pharmacist have extra data on medicines to watch out with or keep away from whereas taking Endep.

Proper Usage of Endep

Observe all instructions given to you by your physician and pharmacist fastidiously. They could differ from the knowledge contained in this leaflet. If you don’t understand the directions on the package, ask your physician or pharmacist.

  • Swallow the tablets complete with a glass of water.
  • Endep could be taken with or with out meals.
  • Endep could be taken as a single dose (eg. at bedtime) or as divided doses (eg. thrice a day). Your physician will advise you.
  • Take your medication at about the identical time every day. Taking it on the similar time every day may have the perfect impact. It’s going to additionally show you how to keep in mind when to take it.


  • Preserve taking Endep for so long as your physician recommends.
  • The size of remedy will rely on how shortly your signs enhance.
  • Most medicines for despair take time to work, so don’t be discouraged if you don’t really feel higher straight away. Some individuals discover an enchancment of their depressive signs after 3 or 4 days. Nevertheless, it might take as much as 4 weeks to really feel the total advantages of Endep.
  • Even while you really feel nicely, your physician could ask you to proceed taking Endep for 3 months or longer to ensure that the advantages final.


  • Most kids reply to remedy within the first few days. Nevertheless, continued remedy is normally required to keep up the response till bed-wetting ends.

Endep Dosage

The dose varies from individual to individual. Your physician will determine the precise dose for you.


Endep is typically started at a low dose and then increased if necessary based on how your symptoms improve and how well you tolerate it.

  • For despair, the same old beginning dose is 75 mg to 150 mg per day in divided doses.
  • For individuals being handled in hospital for his or her despair, the same old beginning dose is 100 mg to 200 mg per day.
  • For the aged, decrease doses are really helpful, as Endep is probably not nicely tolerated on this age group.
  • Your physician could then scale back your dose to 50 mg to 100 mg per day when your depressive signs have improved, relying in your response to Endep.


  • Preserve Endep out of the attain of kids.
  • Don’t give your baby extra Endep than what’s really helpful by your physician.
  • The doses really helpful for bed-wetting are decrease than the doses used to deal with despair and normally rely on the individual’s age and weight.

Missed Dosage

In case you only take one dose a day (at bedtime):

  • In case you neglect to take Endep earlier than going to mattress and get up late within the night time or early within the morning, don’t take the missed dose till you’ve checked together with your physician.
  • You could have problem waking up or expertise drowsiness within the morning or in the course of the day, if you happen to take Endep at these occasions.

In case you take multiple doses a day:

  • Whether it is virtually time to your subsequent dose, skip the dose you missed and take your subsequent dose if you find yourself meant to.
  • In any other case, take the missed dose as quickly as you keep in mind, after which return to taking your tablets as you’d usually.
  • Don’t attempt to make up the dose you missed by taking a double dose.
  • If you’re unsure what to do, ask your physician or pharmacist.
  • When you have bother remembering to take your tablets, ask your pharmacist for some hints.

Endep Storage

  1. Preserve Endep the place kids can’t attain it. A locked cabinet not less than one-and-a-half metres above the bottom is an effective place to retailer medicines.
  2. Preserve your tablets in a cool dry place the place the temperature stays beneath 30°C.
  3. Don’t retailer Endep or some other medication within the lavatory or close to a sink.
  4. Don’t depart Endep within the automobile or on window sills. Warmth and dampness can destroy some medicines.

Disposal: In case your physician tells you to cease taking Endep or your tablets have passed their expiration date, ask your pharmacist what to do with any that can be left over.

Endep Precautions

  • Issues you could do 
    • Inform your physician instantly in case you have any suicidal ideas or different psychological/temper modifications. Sometimes, the signs of despair or different psychiatric circumstances could embrace ideas of harming your self or committing suicide. These signs could proceed or worsen in the course of the first one to 2 months of remedy till the total antidepressant impact of the medication turns into obvious. That is extra prone to happen in kids, adolescents and younger adults underneath 25 years of age.
    • Contact your physician or a psychological well being skilled straight away or go to the closest hospital for remedy if you happen to or somebody is exhibiting any of the next warning indicators of suicide:
      • worsening of your despair
      • ideas or discuss of demise or suicide
      • ideas or discuss of self-harm or hurt to others
      • any current makes an attempt of self-harm
      • improve in aggressive behavior, irritability or some other uncommon modifications in behavior or temper.
        All mentions of suicide or violence have to be taken significantly.
    • Inform your physician if you happen to really feel the tablets are usually not serving to your situation.
    • Preserve your entire appointments together with your physician in order that your progress could be checked.
    • Inform your physician instantly if you happen to grow to be pregnant whereas taking Endep. Don’t cease taking your tablets till you’ve spoken to your physician.
    • Earlier than beginning any new medication, inform your physician or pharmacist that you’re taking Endep.
    • Inform all of the docs, dentists and pharmacists who’re treating you that you’re taking Endep.
    • In case you plan to have surgical procedure, together with dental surgical procedure, inform your physician or dentist that you’re taking Endep. Your physician could ask you to quickly cease taking Endep just a few days earlier than elective surgical procedure.
    • Inform your physician if, for any purpose, you haven’t taken your medication precisely as prescribed. In any other case, your physician might imagine that it was not efficient and alter your remedy unnecessarily.

  • Issues you could not do
    • Don’t drive or function equipment till you understand how Endep impacts you. Endep could scale back your alertness, trigger drowsiness or dizziness in some individuals. In case you expertise any of those signs, don’t drive, function equipment or do anything that may very well be harmful.
    • For a similar causes, kids shouldn’t journey a motorbike, climb timber or do anything that may very well be harmful if they’re drowsy.
    • Don’t cease taking Endep, or decrease the dose, with out checking together with your physician. Don’t let your self run out of your medication over weekends or throughout holidays.
      • Stopping Endep instantly could make you are feeling sick (nauseous), have complications or really feel typically unwell.
      • Your physician will inform you steadily scale back the quantity of Endep you take earlier than stopping utterly.
    • Don’t use Endep to deal with some other circumstances except your physician tells you to.
    • Don’t give Endep to anybody else, even when they’ve the identical situation as you.

  • Issues to watch out of
    • Watch out ingesting alcohol whereas taking Endep.
      • Combining Endep with alcohol could make you extra drowsy or dizzy. Your physician could recommend you keep away from alcohol whereas being handled for despair.
    • Watch out getting up from a sitting or mendacity place.
      • Dizziness, lightheadedness or fainting could happen, particularly while you rise up shortly. Getting up slowly could assist.
    • Inform your physician or dentist in case your mouth continues to really feel dry for greater than 2 weeks.
      • Endep could trigger dry mouth. This may be relieved by frequent sips of water, sucking sugarless lollies or chewing sugarless gum.
      • Nevertheless, persevering with dryness of the mouth could improve the prospect of dental illness, together with tooth decay and gum illness.

Endep Side Effects

Inform your physician or pharmacist as quickly as possible if you don’t really feel well while you’re taking Endep. Endep helps most individuals; however, it might have undesirable negative effects in some individuals. All medicines can have negative effects. Generally, they’re critical, but more often than not, they don’t seem to be. You might want medical treatment if you happen to get one of the negative effects.

Don’t be alarmed by this listing of potential negative effects. You might not expertise any of them. Ask your physician or pharmacist to reply to any questions you might have.

Inform your physician if you happen to discover any of the following, which they usually fear:

  • dry mouth, altered sense of style
  • nausea (feeling sick), vomiting
  • diarrhoea, constipation
  • blurred imaginative and prescient, problem in focusing
  • drowsiness, tiredness, headache
  • dizziness, lightheadedness
  • elevated sweating
  • weight acquire or loss
  • modifications in intercourse drive.

Inform your physician as quickly as potential if you happen to discover any of the next:

  • quick or irregular coronary heart beats
  • bigger breast than regular (in women and men)
  • tingling or numbness of the fingers or toes
  • uncontrolled actions, together with trembling and shaking of the fingers and fingers, twisting actions of the physique, shuffling stroll and stiffness of the legs and arms
  • problem in passing urine
  • indicators of frequent infections akin to fever, chills, sore throat or mouth ulcers
  • yellowing of the eyes or pores and skin (jaundice)
  • uncommon bruising or bleeding
  • feeling anxious, stressed or confused
  • irregular concepts, hallucinations
  • sudden swap of temper to one in every of pleasure, overactivity, talkativeness and uninhibited behavior.

Inform your physician instantly or go to Accident and Emergency at the nearest hospital if you happen to discover any of the following:

  • pores and skin rash, itching, hives
    • swelling of the face or tongue
    • extreme sunburn
    • blistering or swelling of the pores and skin
  • fainting or collapse
  • chest ache
  • seizures or suits.
  • The above negative effects are very critical and should require pressing medical consideration and even hospitalisation.


Information concerning psychotic disorders, included within the review of Endep, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


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This website isn\’t connected with any brands. They own all the brand, logos, and images. This website\’s content is for informational purposes only and not intended as medical advice, diagnosis, or treatment. If you have questions about a medical issue, consult a doctor. Do not reject medical advice or delay in getting it because of this website.

We do not sell medications on this website and instead direct visitors to reliable Internet service providers. So, we save you money, give you the best price, and make it easy and legal for you to get this medicine.

Frequently asked questions

  1. What is Endep?

     Endep belongs to the tricyclic antidepressants. The drug is mostly used to treat depression and obsessive-compulsive disorder (OCD).

  2. What to do if you miss a dose?

    If you miss a dose of Endep, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  3. What if u take too much Endep?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  4. How to store Endep?

    Store your medicines at room temperature between 68-77 F (20-25 C) away from light and moisture. 

  5. What Should I Avoid While Taking Endep?

    Marked drowsiness may occur avoid alcoholic drinks alcohol, sedatives, and tranquillizers may increase drowsiness excitability may occur, especially in children be careful when driving a motor vehicle or operating machinery 

  6. What are the side effects of Endep?

    The medication cannot be used in patients with hypersensitivity to the components of Endep, in patients during acute recovery phase of myocardial infarction, and in patients treated by MAO inhibitors.

  7. What are the Contraindication?

    The medication cannot be used in patients with hypersensitivity to the components of Endep, in patients during acute recovery phase of myocardial infarction, and in patients treated by MAO inhibitors.

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