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Active Ingredient: Caffeine/Ergotamine
Brand(s): Cafergot

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What is Caffeine

Ergotamine has each stimulatory and blocking properties for α-adrenergic and serotonergic receptors and a direct vasoconstrictive impact. Caffeine accelerates and will increase the enteral resorption of ergotamine.

Caffeine Drug Recommendation

Suggestion for the therapy of migraine assaults, paracetamol in sufficiently excessive doses is most well-liked, primarily based on the uncomfortable side effects. Second alternative with related efficacy however extra uncomfortable side effects are NSAIDs (acetylsalicylic acid, ibuprofen, naproxen) and oral triptans. In case of nausea and vomiting, an antiemetic (domperidone, metoclopramide) could also be taken together with the analgesic if obligatory. On account of uncomfortable side effects, using ergotamine is proscribed.

Prophylaxis needs to be thought of if there are two or extra assaults monthly.


  • acute assaults of migraine;
  • migraine variants;
  • associated vascular complications with and with out aura.

What Should You Discuss To Your Doctor Before Using This Medicine

  • Pregnancy
    • Because of its pharmacological exercise (uterotonic motion and constriction of the placental and umbilical vessels), it’s doable that it could be dangerous to the foetus (intrauterine dying) when used throughout being pregnant and start.
  • Lactation
    • Ergotamine passes into breast milk. Don’t use throughout being pregnant and lactation.


  • Peripheralcerebral or coronary vascular illness;
  • Shock;
  • Extreme hypertension;
  • Coronary heart failure;
  • Extreme hepatic and renal insufficiency;
  • Sepsis;
  • Hyperthyroidism.

Caffeine Drug Interactions

Use of vasoconstrictive brokers (equivalent to ergot alkaloids, sumatriptan), CYP3A4 inhibitors equivalent to:

  • macrolide antibiotics (equivalent to clarithromycin)
  • HIV inhibitors (equivalent to ritonavir)
  • azole antimycotics (equivalent to ketoconazole)

Concomitant use of dopamine or B-blockers or nicotine will increase the danger of peripheral vasoconstriction.

Caffeine Dosage

  • Migraine
    • Adults:
      • At first signal of assault: 1-2 mg ergotamine, repeat if obligatory after no less than 1 hour;
      • max. 4 mg ergotamine per assault, max. 1×/w.

Caffeine Precautions

Ergotamine should in principle not be administered daily. If symptoms such as tingling in fingers or toes occur, discontinue use immediately. Frequent administration may increase the frequency of headaches and provoke headaches on discontinuation of treatment. The risk of fibrotic changes is greater with overuse. Caution is advised in mild to moderate hepatic disease. The experience in children is limited.

Cafergot Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur:

  • Nausea and vomiting
  • Hypersensitivity reactions equivalent to:
    • pores and skin rash
    • facial oedema
    • dyspnoea
    • elevated blood stress
    • dizziness
    • stomach ache
    • diarrhoea

In prone people and after common use, ergotamine might trigger ergotism (generally as little as 2 mg ergotamine per week), with signs of paraesthesia, ache and sensation of weak point in extremities or peripheral vasoconstriction and in some instances irreversible vascular harm. After years of extreme ergotamine use, fibrosis might happen, notably within the pleura and the retroperitoneum, not often within the coronary heart valves. Myocardial ischaemia, not often myocardial infarction.


Information concerning psychotic disorders, included within the review of Caffeine, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


⚠Disclaimer of liability

This website isn\’t connected with any brands. They own all the brand, logos, and images. This website’s content is for informational purposes only and not intended as medical advice, diagnosis, or treatment. If you have questions about a medical issue, consult a doctor. Do not reject medical advice or delay in getting it because of this website.

We do not sell medications on this website and instead direct visitors to reliable Internet service providers. So, we save you money, give you the best price, and make it easy and legal for you to get this medicine.

Frequently asked questions

  1. What is Caffeine Cafergot?

    Cafergot is the proprietary name of a drug that consists of ergotamine tartrate and caffeine. 
    This combination is used to treat vascular headaches such as migraine headache.

  2. What to do if you miss a dose?

    If you miss a dose of Caffeine/Ergotamine, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  3. What if u take too much Cafergot?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  4. How to store Caffeine ?

    Store at room temperature between 15-25 degrees C away from light and moisture, kids and pets. 

  5. What Should I Avoid While Taking Caffeine ?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Cafergot. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  6. What are the side effects of Caffeine Cafergot?

    Because the vasoconstrictive effects of ergotamine and caffeine are not selective for the brain, side effects due to systemic vasoconstriction may occur.  Cold feet or hands, angina or dizziness are some examples.

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