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Active Ingredient: Donepezil
Brand(s): Aricept

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What is Donepezil

Donepezil is an irregular antipsychotic medicine. Blocks dopamine receptors of the CNS as well as conflicts with the dopamine button in the basic ganglia as well as in the limbic system, a component of the neonatal brain. It is taken for hypersensitivity, disorders of the hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychoses, myasthenia, and comas.

Aricept Drug Uses

Donepezil is used to help people with mild, moderate, or severe Alzheimer’s disease who are losing their memories and having other changes in their minds. Donepezil will not cure Alzheimer’s disease, and it will not stop the disease from getting worse. However, it can improve thinking ability in some patients.

What Should You Discuss To Your Doctor Before Using This Medicine

  1. Anesthesia: ARICEPT, as a cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.

  2. Cardiovascular Conditions: Because of their pharmacological action, cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes. This effect may manifest as bradycardia or heart block in patients both with and without known underlying cardiac conduction abnormalities. Syncopal episodes have been reported in association with the use of ARICEPT.

  3. Nausea And Vomiting: ARICEPT, as a predictable consequence of its pharmacological properties, has been shown to produce diarrhea, nausea, and vomiting. These effects, when they occur, appear more frequently with the 10 mg/day dose than with the 5 mg/day dose, and more frequently with the 23 mg dose than with the 10 mg dose. Specifically, in a controlled trial that compared a dose of 23 mg/day to 10 mg/day in patients who had been treated with donepezil 10 mg/day for at least three months, the incidence of nausea in the 23 mg group was markedly greater than in the patients who continued on 10 mg/day (11.8% vs. 3.4%, respectively), and the incidence of vomiting in the 23 mg group was markedly greater than in the 10 mg group (9.2% vs. 2.5%, respectively). The percent of patients who discontinued treatment due to vomiting in the 23 mg group was markedly higher than in the 10 mg group (2.9% vs. 0.4%, respectively).

  4. Weight Loss: Weight loss was reported as an adverse reaction in 4.7% of patients assigned to ARICEPT in a dose of 23 mg/day compared to 2.5% of patients assigned to 10 mg/day. Compared to their baseline weights, 8.4% of patients taking 23 mg/day were found to have a weight decrease of ≥7% by the end of the study, while 4.9% of patients taking 10 mg/day were found to have weight loss of ≥7% at the end of the study.

  5. Genitourinary Conditions: Although not observed in clinical trials of ARICEPT, cholinomimetics may cause bladder outflow obstruction.

  6. Neurological Conditions: Seizures: Cholinomimetics are believed to have some potential to cause generalized convulsions. However, seizure activity also may be a manifestation of Alzheimer’s disease.

  7. Pulmonary Conditions: Because of their cholinomimetic actions, cholinesterase inhibitors should be prescribed with care to patients with a history of asthma or obstructive pulmonary disease.

Donepezil Drug Interactions

Although certain medicines should not be used together at all, in other cases, two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose or take other precautions that are necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions were chosen because they could be important, but they are not necessarily all of them.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Bepridil
  • Cisapride
  • Dronedarone
  • Fluconazole
  • Ketoconazole
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions were chosen because they could be important, but they are not necessarily all of them.

Using this medicine with any of the following is usually not recommended but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine or give you special instructions about the use of food, alcohol, or tobacco.

  • Bitter Orange
  • Grapefruit Juice

Other Medical Problems Aricept

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Asthma
  • Lung disease
  • Peptic ulcers,
  • Seizures
  • Urinary tract blockage or difficult urination
  • Heart problems
  • Liver disease
  • Low body weight (below 50 kilograms or 110 pounds)

Proper Usage of Donepezil

Take this medicine exactly as directed by your doctor in order to improve your condition as much as possible. Do not take more of it or less of it, and do not take it more or less often than your doctor ordered.

Donepezil should be taken at bedtime unless otherwise directed by your doctor. It may be taken with or without food, on a full or empty stomach. Swallow the tablet whole. Do not crush, break, or chew it.

For patients using the oral disintegrating tablet form of this medicine:

  • Make sure your hands are dry.
  • Do not push the tablet through the foil backing of the package. Instead, gently peel back the foil backing and remove the tablet.
  • Immediately place the tablet on top of the tongue.
  • Do not swallow the tablet whole. The tablet will dissolve in seconds, and you may swallow it with your saliva. You should drink a glass of water after the tablet has dissolved.

For patients taking the oral solution form of this medicine:

  • Shake the bottle well before measuring the dose.
  • Use a specially marked measuring spoon, a plastic syringe, or a small marked measuring cup to measure each dose accurately. The average household teaspoon may not hold the right amount of liquid.
  • If your dose is 5 mg, you should take 5 mL of this medicine.
  • If your dose is 10 mg, you should take 10 mL of this medicine.

Donepezil Dosage

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage forms (oral disintegrating tablets, oral solution, and tablets):
    • For mild to moderate Alzheimer’s disease:
      • Adults—5 milligrams (mg) taken at bedtime. Your doctor may increase your dose as needed. However, the dose usually is not more than 10 mg per day.
      • Children—Use and dose must be determined by your doctor.
    • For moderate to severe Alzheimer’s disease:
      • Adults—10 milligrams (mg) taken at bedtime. Your doctor may increase your dose as needed. However, the dose usually is not more than 23 mg per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dosage

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not take double doses.

Aricept Storage

  1. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
  2. Ask your healthcare professional how you should dispose of any medicine you do not use.
  3. Keep out of the reach of children.
  4. Do not keep outdated medicine or medicine no longer needed.

Donepezil Precautions

It is important that your doctor check your progress at regular visits. This is necessary to allow dose adjustments and reduce any unwanted effects. Before you have any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Taking donepezil together with certain medicines that are used during surgery, dental treatment, or emergency treatments may increase the effects of those medicines and cause unwanted effects.

This medicine may cause some people to become dizzy or drowsy, to have blurred vision, or to have problems with clumsiness or unsteadiness. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, well-coordinated, and able to see clearly.

Some people who have used this medicine have developed problems such as nausea, severe vomiting, loss of appetite, diarrhoea, and weight loss. Talk with your doctor before using this medicine if you have any concerns.

Donepezil Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do, they may need medical attention. Check with your doctor as soon as possible if any of the following side effects occur:

  1. Diarrhea
  2. loss of appetite
  3. muscle cramps
  4. nausea
  5. trouble in sleeping
  6. unusual tiredness or weakness
  7. vomiting

Other negative effects not listed can also happen to some sufferers. If you discover some other results, verify them with your healthcare professional. Call your physician for a medical recommendation about negative effects.


Information concerning psychotic disorders, included in the review of Donepezil, is used exclusively for the informative features and should not be considered an alternative to licenced healthcare or a referral to the well-being treatment distributor.


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This website isn\’t connected with any brands. They own all the brand, logos, and images. This website\’s content is for informational purposes only and not intended as medical advice, diagnosis, or treatment. If you have questions about a medical issue, consult a doctor. Do not reject medical advice or delay in getting it because of this website.

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Frequently asked questions

  1. What is Donepezil Aricept?

    Donepezil contains the active ingredient donepezil hydrochloride, which is an inhibitor of the enzyme acetylcholinesterase and, as a result, blocks the disintegration of acetylcholine. Acetylcholine is responsible for the transfer of excitation in the central nervous system, and donepezil slows the progression of dementia caused by Alzheimer’s disease.

  2. What to do if you miss a dose?

    If you forget to take a dose of Donepezil, you should take it as soon as you remember. However, if it is almost time for your next dose, you should skip the dose you missed and go back to your regular dosing schedule. Never double the amount of medication that you are supposed to take.

  3. What if u take too much Aricept?

    In the event that you experience an overdose, contact your primary care physician or the emergency room of the hospital that is closest to you. If necessary, you may also wish to speak with the hospital’s poison control centre.

  4. How to store Donepezil?

    Keep away from moisture and direct sunlight while storing at a temperature between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit).

  5. What Should I Avoid While Taking Donepezil?

    While you are taking Aricept, you should avoid drinking alcohol or using illegal drugs because doing so could reduce the benefits of the treatment (for example, it could make your confusion even worse) and increase the adverse effects (for example, it could make you more sedated).

  6. What are the side effects of Donepezil Aricept?

    This medication is typically well tolerated, and adverse reactions are not to be expected. The most common adverse effects include chest pain or tightness, tingling, flushing, weakness, dizziness, abdominal discomfort, sweating, nasal irritation, and reactions at the injection site.

  7. What are the Contraindication?

    Patients who have an allergy to donepezil or any derivatives of piperidine are not candidates for treatment with Aricept.

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