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What is estrace or estradiol?

Estrace belongs to the class of medications called oestrogen replacement therapy. Specific estrogen-receptors are located in different organs (in the uterus, vagina, urethra, mammary glands, liver, hypothalamus, and pituitary) and stimulate the development and growth of female sex organs starting from puberty: uterus, fallopian tubes, vagina, stroma and ducts of mammary glands, pigmentation of nipples and genitals, the formation of secondary sexual characteristics of the female type, and the formation of epiphyses of long bones. Oestrogen is responsible for the timely and regular rejection of the endometrium and bleeding. In high concentrations, oestrogen causes endometrial hyperplasia, suppresses lactation, and inhibits bone resorption. Estrace is used to treat menopause symptoms, which include hot flashes and vaginal dryness, burning, and irritation. It is also used for the treatment of cancer in women and men and osteoporosis.

Dosage and direction of

Follow all recommendations exactly as prescribed by your doctor. Estrace tablets should be taken one time a day. In women, a cyclic regimen may be administered. For 23 days, the tablets are taken, followed by the next 5 days without any medication intake. After that, the cycle resumes. The adhesive part of the patch should be stuck to a hairless part of the trunk (hips, shoulders but not on the breasts). Choose a non-irritated healthy skin site. Change the place of plaster application every other week. Stick it immediately to the skin after you remove the protective layer and press it tight to your skin for at least 10 seconds.


Before taking Estrace, inform your doctor if you have severe blood diseases, circulation problems, hormone-related cancer (breast or uterine cancer), or excessive vaginal bleeding. Long-term treatment by Estrace may result in an increased risk of breast cancer, heart attack, or stroke and cannot be used in pregnant women.


thrombophlebitis or thromboembolic disease in active phase (excluding treatment of breast and prostate cancer). Carefulness should be exercised in patients with thrombophlebitis, thrombosis or thromboembolism (during the taking of estrogens in history); familial hyperlipoproteinemia, pancreatitis, endometriosis, gallbladder disease in history, severe liver failure, jaundice, hepatic porphyria, hypercalcemia associated with metastases in bones caused by breast cancer. only for treatment of breast and prostate cancer; diseases of the coronary or cerebral vessels; active thrombophlebitis or thromboembolic disease.

Possible side effect

  • Common side effects include:
  • breast pain or tenderness;
  • headache;
  • hair loss;
  • spotting or breakthrough bleeding;
  • mild nausea or vomiting.
  • stomach cramps or bloating.

Serious side effects are allergic reactions.

  • rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue;
  • back pain;
  • breast discharge or lump in the breast;
  • calf or leg pain or swelling.
  • Chest pain
  • Coughing up blood
  • dark urine;
  • depression; dizziness;
  • fainting;
  • fever;
  • memory problems;
  • mental or mood changes;
  • muscle pain; one-sided weakness;
  • painful or difficult urination;
  • persistent or severe breast pain or tenderness;
  • persistent or severe headache, nausea, or vomiting;
  • severe stomach pain or swelling.
  • slurred speech;
  • Suddenly, shortness of breath;
  • a sunburn-like rash;
  • swelling of hands, legs, or feet;
  • Unusual vaginal bleeding, discharge, itching, or odour;
  • vision changes;
  • vomiting;
  • weakness or numbness of an arm or leg;
  • yellowing of the skin or eyes.

Drug interaction

Oestrogen can inhibit the metabolism of cyclosporine, resulting in an increase in its levels in the blood and kidney and/or liver damage. Oestrogen is able to increase the risk of liver disease in patients treated by dantrolene. Known to affect clot formation, Estrace should be used carefully together with warfarin (Coumadin). Enhanced metabolism and excretion of Estrace may be stipulated by rifampin, barbiturates, carbamazepine (Tegretol), griseofulvin, phenytoin (Dilantin), and primidone.

Missed dose

If you missed a dose, take it as soon as you remember, but not if it is almost time for the next intake by your schedule. If so, skip the missed dose. Do not try to make up for a missed dose by taking an extra one.


If you suspect that you took too much of the medication, seek immediate medical attention. Your symptoms may appear as nausea, vomiting, or vaginal bleeding.


Store Estrace in a dry, tight container away from sunlight at a room temperature between 15–30 C (59–86 F) away from children and pets.

⚠Disclaimer of liability

This website isn\’t connected with any brands. They own all the brand, logos, and images. This website\’s content is for informational purposes only and not intended as medical advice, diagnosis, or treatment. If you have questions about a medical issue, consult a doctor. Do not reject medical advice or delay in getting it because of this website.

On this website we do not sell any medications and refer visitors to trusted Internet providers. In this way, we save you and the best price for many people, and you can easily and legally obtain this powerful medicine.

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Frequently asked questions

  1. What is Estrace?

    You are using this medicine as a woman during menopause. The medicine contains estradiol, a primary form of estrogen. Estradiol is available in patches of 3.8 and 7.6 mg of estradiol or tablets. The patches release this substance gradually throughout the day. The patches containing 3.8 mg of Estrace release 50 micrograms per 24 hours and the patches containing 7.6 mg of estradiol release 100 micrograms per 24 hours. Look at all the different types of Estrace here.

  2. Why and when should you use Estrace?

    Estrace or Estradiol is a drug used to reduce menopause symptoms in women. Menopause is a process in the body where the ovaries stop producing eggs. As a result, the woman no longer has her monthly period and her periods will be irregular at first and then stop. The amount of estrogen gradually decreases in the body. This may also cause you to experience psychological and physical symptoms. This usually happens between the ages of 44 and 55.

  3. How effective is Estrace?

    Estrace is effective to treat menopause symptoms. The symptoms: stiff joints, mood swings, difficulty sleeping… will decrease when using this drug. Women can suffer greatly from these symptoms. This can have a psychological and a physical impact on their lives. In this case, it is advisable to take medication. In function of their well-being.. Look at all the different types of Estrace here.

  4. What are the side effects of Estrace?

    Like other medications, Estrace can have side effects. It is important to know about these beforehand so you know what to expect. Do you recognize signs of an allergic reaction (such as difficulty breathing or swelling in the mouth and throat), of a blood clot (such as chest pain) or of breast cancer (such as changes to the areola)? If so, get medical attention right away.

    -Frequently (in 1 or more than 1 in 10 women): skin irritation, swelling or bleeding at the site of the patch, headache, painful or irregular menstruation;

    -Regularly (in 1 or less than 1 in 10 women): trouble sleeping, depression, diarrhea, nausea, dry or itchy skin, rash, larger breasts, acne, irregular vaginal bleeding, violent contractions of the uterus, fluid retention, changes in weight, feeling weakened, pain in the limbs, back pain;

    -Less frequently (in 1 or less than 1 in 100 women): feeling faint, migraines, hypertension (high blood pressure), vomiting, changed liver values on blood tests, skin discoloration;. Look at all the different types of Estrace here.

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