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What is Metformin or Glucophage?

Glucophage is an oral diabetes medicine used to treat type 2 of diabetes. Its active substance is Metformin which belongs to the biguanide class of substances. It reduces the concentration of glucose in blood suppressing metabolism of glucose in the liver, reducing the absorption of glucose from the gastrointestinal tract, and enhancing its utilization in tissues. Glucophage stabilizes or reduces body weight. The therapeutic effect is not observed in the absence of insulin in the blood. It does not cause hypoglycemic reactions. It improves fibrinolytic properties of blood. It I used to treat diabetes mellitus (type 2) in adults also in patients for who treatment with sulfonylurea was ineffective, especially in cases followed by obesity.

How does Metformin work?

A patient dealing with type 2 diabetes has a pancreas that does not produce enough insulin or does not respond properly to the body’s production of insulin. This results in elevated blood sugar levels. Excessive blood sugar can pose health risks of a serious nature. Metformin lowers blood sugar levels while reducing appetite.

How is Metformin used and what is the dosage?

Always use this medicine exactly as your doctor or pharmacist has told you. If you are in doubt about the correct use? If so, contact your doctor or pharmacist.Metformin is available in 500 mg, 850 mg, and 1000 mg. The dosage also depends on the patient’s age. For both children (10 years and older) and adults, the dose is usually 500 mg or 850 mg mg, once a day. The maximum dosage for children is 2000 mg, spread over 2-3 intakes. For adults, the maximum dosage is 3000 mg spread over 2-3 intakes. Tablets should be taken during or after meals. Swallow whole with water.


This medication is able to cause a life-threatening condition in some people which is characterized by weakness, increasing sleepiness, slow heartbeat, cold feeling, muscle pain, abdominal pain, shortness of breath, feeling light-headed, and fainting. It is called lactic acidosis. If you experience such symptoms get immediate medical attention. Also be attentive to symptoms of low blood sugar which include hunger, confusion, irritability, drowsiness, headache, weakness, fast heartbeat, tremors, sweating, seizure and have a source of sugar at hand always. Avoid drinking alcohol.


Hypersensitivity, hyperglycemic coma, ketoacidosis, kidney failure, liver disease, heart failure, acute myocardial infarction, respiratory failure, dehydration, infectious diseases, extensive surgery and trauma, alcoholism, reduced-calorie diet (less than 1000 kcal/day), lactic acidosis (including history), pregnancy, breastfeeding. The drug is not prescribed to take 2 days before surgery, radioisotope and X-ray examinations, CAT scanning (CT). Glucophage is contraindicated in patients over 60 y.o., or doing hard physical work (risk of lactic acidosis increases).

Side effects

The following side effects are most common and are rather severe to stop taking the medication:

  • swelling or rapid weight gain,
  • nausea,
  • vomiting,
  • gas,
  • bloating,
  • diarrhoea and loss of appetite.

In case of lactic acidosis also get emergency medical help:

  • weakness,
  • increasing drowsiness,
  • slow heartbeat,
  • cold feeling,
  • shortness of breath,
  • abdominal pain,
  • muscle pain,
  • lightheadedness, and fainting.

An allergic reaction is also possible:

  • hives,
  • swelling,
  • rash.

Drug interaction

Cimetidine (Tagamet) increases blood levels of Glucophage affecting its metabolism. Glucophage is not compatible with alcohol. Concomitant administration with indirect anticoagulants and Cimetidine should be done with cautiousness. Glucophage enhances metabolism of Furosemide. Derivatives of sulfonylurea, insulin, acarbose, inhibitors of MAO, oxytetracycline, cyclophosphamide and salicylates increase the effects of Glucophage. Decrease of hypoglycemic effect of Glucophage is caused by co-administration with thyroid medicines, birth control pills and other hormones, Epinephrine, Glucagon, thiazide diuretics, nicotinic acid derivates.

Missed dose

If you forgot to take your dose in time, please do it as soon as you remember. But do not take if it is too late or time for your next dose is in a short while. Do not take double doses of this medication or extra doses of it. Take your usual dose next day in the same regularly time.


Symptoms of Glucophage overdose are ones of low blood sugar: hunger, confusion, irritability, drowsiness, headache, weakness,, tremors, sweating, fast heartbeat, seizure and have a source of sugar at hand always. If you experience one of them or any unusual symptoms call your doctor immediately.


Store at room temperature between 20-25 C (68-77 F). Store away from moisture, heat, and sunlight. It is not recommended to store in a bathroom and places available for children.

Disclaimer of liability

This website isn\’t connected with any brands. They own all the brand, logos, and images. This website\’s content is for informational purposes only and not intended as medical advice, diagnosis, or treatment. If you have questions about a medical issue, consult a doctor. Do not reject medical advice or delay in getting it because of this website.

We do not sell medications on this website and instead direct visitors to reliable Internet service providers. So, we save you money, give you the best price, and make it easy and legal for you to get this medicine.

Frequently asked questions

  1. What is Metformin?

    Alprazolam, better known under the brand name Xanax, is a medicine that is mainly used for the suppression of agitation, anxiety and tension. Alprazolam does not cure the underlying causes of these complaints. It is a symptom-fighting medicine: it is very effective at temporarily suppressing symptoms.

    Therefore, the medicine is often prescribed for a short period of time. The period of reduced complaints can then be used to treat the underlying causes of the complaints with therapy or other medicines. Look at all the different types of Metformin here.

  2. How long does Metformin work?

    For the treatment of anxiety, panic attacks and problems falling asleep, mainly short-acting benzos are used, such as Xanax, oxazepam and temazepam. These drugs work after about 30 minutes and the effect lasts for about 6 hours.

    For problems with sleeping through, mainly medium-acting benzos such as lorazepam are used. Long-acting benzos, including tramadol, start to work after a few hours and provide relief for 12 to 24 hours. These drugs are mainly prescribed for chronic anxiety and restlessness.

  3. How long can I use Metformin without risks?

    Xanax is a drug that is meant to be used for a short period only. It is recommended that the drug be tapered after 2 weeks and stopped completely after 4 weeks. This prevents the development of physical dependence.
    An alprazolam treatment provides a period of relaxation, rest and calm. This makes it possible to tackle the underlying causes of the complaints more effectively. This can be achieved by therapeutic or psychological treatments, but also by relaxation exercises, meditation and lifestyle coaching.. Look at all the different types of Metformin here.

  4. What are the side effects of Metformin?

    Suddenly stopping the use of alprazolam can cause unpleasant withdrawal symptoms and side effects. These withdrawal symptoms last for about 1 to 2 weeks:

    1. Insomnia
    2. Anxiety
    3. Irritability
    4. Restlessness
    5. Jittery feeling
    6. Muscle cramps and muscle pain
    7. Palpitations
    8. Sweating
    9. Diarrhoea and stomach ache
    10. Shaking
    11. Hypersensitivity to light, sound and touch

    Abruptly stopping alprazolam can therefore cause the same symptoms as the ones you were taking it for in the first place. Look at all the different types of Metformin here.

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