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Active Ingredient: Minocycline
Brand Name: Minocin

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What is Minocycline

Minocycline binds to the 30S and 50S parts of the ribosomes within the bacterial cell, thereby inhibiting protein synthesis. The spectrum of motion includes gram-positive and gram-negative microorganisms, intracellular microorganisms, and spirochetes. Minocycline has the next in vitro exercise in opposition to Gram-positive micro organism than tetracycline. Cross-resistance is widespread amongst tetracyclines; nevertheless, relying on the resistance mechanism, minocycline can nonetheless be efficient in opposition to (particularly Gram-positive) microorganisms which can be immune to different tetracyclines.

Minocycline Drug Recommendation

Within the therapy of common infections, doxycycline and minocycline are the most well-liked among the group of tetracyclines due to their uncomfortable side effects, interactions, and pharmacokinetic parameters.

For the therapy of pneumonia (CAP), acute pharyngotonsillitis, or urinary tract infections, minocycline needs to be thought of solely on the premise of an investigation of the nature and susceptibility of the causative agent; this investigation is critical if the brokers really useful for the preliminary empirical therapy are inadequate. 

Minocycline Indications

  • Infections by micro-organisms delicate to minocycline equivalent to:
    • respiratory tract infections (together with ENT infections);
    • pores and skin and mushy tissue infections, together with extreme (inflammatory) pimples vulgaris;
    • infections of the urogenital system;
    • infections of the gastrointestinal tract;
    • trachoma (eye an infection brought on by Chlamydia trachomatis).
  • In case of hypersensitivity to β-lactam antibiotics additionally:
    • Actinomycosis;
    • Anthrax;
    • Syphilis;
    • Gonorrhoea;
    • Infections brought on by Listeria monocytogenes.

What Should You Discuss To Your Doctor Before Using This Medicine

  • Being pregnant
    • Minocycline crosses the placenta.
    • Teratogenesis: Human observations have proven that minocycline can decelerate osteogenesis, particularly within the second and third trimesters, leading to extra brittle bones and adversely affecting tooth growth.
    • Pharmacological impact: The danger of hepatotoxic results within the mom will increase with excessive doses, particularly when used throughout the second half of being pregnant.

  • Lactation
    • Transition in breast milk: Sure, in small quantities.
    • Pharmacological impact: Attainable antagonistic results on bone and tooth growth within the toddler. Nevertheless, based on Lareb, results on the toddler throughout a brief course of therapy have by no means been reported. In principle, it’s doable to affect the toddler’s intestinal flora, however this can at most result in diarrhoea.
    • Suggestion: Use is contraindicated based on the producer. Based on Lareb, part of the inactivation is because of calcium current in breast milk (by complicated formation). For minocycline and doxycycline, the complicated formation is lower than for different tetracyclines, so that there’s an elevated threat of absorption by the toddler. In case of a brief course (< 3 weeks), enamel and bones are unlikely to be affected by the minimal quantities. Quick-term use in all probability protected when used as directed. In case of long-term use, breast-feeding needs to be discouraged.
  • Contraindications
    • extreme hepatic impairment;
    • hypersensitivity to tetracyclines;
    • youngsters beneath 8 years of age;

Minocycline Drug Interactions

Keep away from administration instantly before, throughout, or after a course of (oral) retinoids because of the elevated threat of intracranial stress.

  1. Oral preparations containing magnesium, bismuth, aluminium, calcium, zinc and iron (e.g. antacids, multivitamin and mineral preparations), activated charcoal and ion exchangers scale back the absorption of minocycline; take minocycline no less than 2 hours earlier than or 4 hours after these preparations.
  2. Tetracyclines antagonise in vitro the motion of bactericidal antibiotics; their scientific relevance has solely been demonstrated in life-threatening infections (equivalent to meningitis, endocarditis, sepsis) and in sufferers with extreme neutropenia; in these instances, keep away from the mix.
  3. The impact of vitamin Okay antagonists could also be elevated; test the INR extra usually if used collectively.
  4. The danger of nephrotoxic reactions will increase with the concomitant use of methoxyflurane and associated anaesthetics.
  5. Use warning when combining with probably hepatotoxic medicines.
  6. Don’t use concurrently with brokers that inhibit peristalsis.
  7. Barbiturates, carbamazepine and phenytoin might speed up the excretion of minocycline.

Minocycline Dosage

  1. Adults and kids ≥ 12 years
    • Preliminary dose 200 mg, adopted by 100 mg 1-2×/day.
    • Period of therapy: Proceed remedy for 1-3 days after the attribute signs or fever have resolved. Nevertheless, an an infection with Streptococcus haemolyticus (group A), of which the susceptibility has been decided, needs to be handled for no less than 10 days.
  2. Kids 9-12 years
    • Beginning dose 4 mg/kg physique weight, adopted by 2 mg/kg physique weight day by day; this corresponds to a beginning dose of 100-200 mg, adopted by 50-100 mg 2×/day.
    • Period of therapy: Proceed remedy for 1-3 days after the attribute signs or fever have disappeared. Nevertheless, an an infection by Streptococcus haemolyticus (group A), of which the susceptibility has been decided, needs to be handled for no less than 10 days.

  3. Gonococcal urethritis
    • Adults
      • Beginning dose 200 mg, adopted by 100 mg 2×/day for no less than 4 days (ladies generally as much as 10 days), adopted by a management tradition 2-3 days after therapy. In males, a single dose of 200-300 mg has additionally been proven to be efficient in > 90% of instances.

  4. Non-gonococcal urethritis
    • Adults
      • 100-200 mg/day for 7 days.

  5. Extreme pimples vulgaris
    • Adults and kids ≥ 9 years
      • Beginning and upkeep dose: 50 mg 2×/day (each 12 hours). After discount of the inflammatory section, scale back the upkeep dose to 50 mg 1×/day or 100 mg each 2 days. Remedy needs to be continued for no less than 4-6 weeks; most period of therapy is 6 months. In case of inadequate response throughout the first weeks, discontinue therapy.

  6. Diminished liver operate: use with warning (see Warnings and Precautions part behind Liver and renal operate); don’t use in case of severely impaired liver operate (see Contraindications part).
  7. Diminished renal operate: the producer recommends: lowering the entire dose or lowering the really useful particular person dose and/or extending the administration intervals.
  8. Administration: due to the danger of esophageal and/or gastric irritation, take the tablets complete in a sitting or standing place with loads of water or meals, not earlier than going to sleep. Don’t lie down instantly after taking the tablets. Simultaneous consumption with milk merchandise has a slight impact on the absorption.

Signs of Overdose

  • Liver toxicity with signs of vomiting
  • fever episodes
  • jaundice
  • haematomas
  • melena
  • uraemia
  • elevated transaminase ranges
  • prolongation of prothrombin time

Minocycline Precautions

Take into account therapy of youngsters aged 9-12 years solely when different choices are ineffective or contraindicated. Deposition in rising dental tissue causes everlasting discoloration of the enamel; due to this fact utility in youngsters beneath 8 years of age is contraindicated.

Cross-sensitivity and cross-resistance exist between tetracyclines; due to this fact, caution needs to be exercised in cases of earlier hypersensitivity reactions. Resistance can develop quickly. Concentrate on superinfections by resistant micro-organisms. In the case of superinfection, discontinue administration. If extreme diarrhoea with fever happens throughout therapy, take into account the analysis of pseudomembranous colitis or staphylococcal enteritis.

Hepatic and renal operate: Tetracyclines might trigger a rise in blood urea ranges attributable to their catabolic motion. In the case of renal impairment, larger concentrations of tetracyclines can result in uraemia, hyperphosphataemia, and acidosis. In cases of renal or hepatic impairment, even regular doses can result in extreme systemic accumulation of the drug and probably liver toxicity. In the case of mild to reasonable hepatic impairment, intently monitor the therapy and hepatic function and modify the dosage if necessary.

In the case of long-term therapy, monitoring of renal, hepatic, and haematological parameters is really useful. In the case of long-term use, additionally take into account monitoring for thyroid cancers, as instances of irregular thyroid function, thyroiditis, thyroid nodules, goitre, and thyroid cancers have been reported. Lengthy-term use may additionally result in vitamin B deficiency by way of eradication of vitamin B-producing micro organism within the intestine.

Publicity to direct sunlight or UV rays throughout use might trigger photodermatitis (manifest as abnormally extreme sunburn); discontinue therapy at the first signal of pores and skin erythema.

Benign intracranial hypertension (adults) and a bombarding fontanel (younger youngsters) are often reversible after cessation of therapy; nevertheless, persistent signs (headache, imaginative and prescient issues) are doable. Vestibular antagonistic occasions are reversible; if dizziness happens, modify the dose or discontinue therapy. Cease therapy if different vestibular signs happen. 

Additionally, discontinue therapy if signs equivalent to imaginative and prescient impairment, scotomas, or hallucinations happen. Use with warning in myasthenia gravis attributable to weak neuromuscular blockade functionality of tetracyclines. For the therapy of fertile ladies, see also the part about being pregnant.

Diagnostic assessments: Tetracyclines might intrude with nonspecific glucose, protein and urobilinogen determinations within the urine, false optimistic urine catecholamine concentrations may additionally happen.

Minocin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur, they may require medical attention. Check with your doctor immediately if any of the following side effects occur:

  • angioedema
  • rash
  • urticaria
  • fever
  • eosinophilia
  • neutropenia
  • thrombocytopenia
  • anaphylaxis
  • anaphylactoid purpura
  • pericarditis
  • transient lupus-like syndrome
  • exacerbation of systemic lupus erythematodes (SLE)
  • pulmonary infiltrates with eosinophils
  • serum sickness-like response
  • vasculitis
  • polyarthralgia
  • Bombarding fontanel (youngsters)
  • benign intracranial hypertension (adults)
  • paraesthesia
  • convulsions
  • sedation
  • black tongue
  • discolouration of enamel
  • stomatitis
  • anorexia
  • nausea
  • vomiting
  • oesophageal ulcers


Information concerning psychotic disorders, included within the review of Minocycline, is used for the informative features exclusively and should not be thought of as an alternative to licenced healthcare or referral from the well-being treatment distributor.


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Frequently asked questions

  1. What is Minocycline Minocin?

    Minocin is used to treat certain infections.It is a tetracycline antibiotic. It works by slowing the growth of certain bacteria and allowing the body’s immune system to kill them. It may also be used with other medicines to treat severe acne.

  2. What to do if you miss a dose?

    If you miss a dose of Minocycline, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  3. What if u take too much Minocin?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  4. How to store Minocycline?

    Store Minocin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed, light-resistant container. 

  5. What Should I Avoid While Taking Minocycline?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Minocin. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  6. What are the side effects of Minocycline Minocin?

    The common side effects include dizziness; drowsiness; lightheadedness; loss of appetite; nausea; stomach upset; vomiting. 

  7. What are the Contraindication?

    Do not use Minocin if you have an allergy to its components, you are taking acitretin, isotretinoin, methoxyflurane, or penicillin.

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