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What is pioglitazone?

Metformin (pioglitazone) is a drug that requires a prescription. There are two forms of oral immediate-release tablets: oral immediate-release tablets and oral extended-release tablets.

Actoplus Met (immediate-release) and Actoplus with XR are brand-name medicines that comprise metformin and pioglitazone (extended-release). A generic model of the immediate-release capsule can also be obtained. Generic medicines are regularly cheaper than their brand-name counterparts. They will not be accessible in every energy or kind as brand-name medicines in some circumstances.

Metformin/pioglitazone is a single-dose mixture of two medicines. It’s crucial to grasp all the medicines within the combo as each one could have a definite impact on you.

A combination remedy with metformin and pioglitazone is an option. That means you will have to mix it with different medicines.


Before you begin taking Actos pioglitazone, and each time you get a refill, learn the medication guide issued by your pharmacist. Inquire with your physician or pharmacist if you have any questions.

Take this medicine by mouth as soon as you start the day, with or without meals, as instructed by your physician. The dosage is decided by your medical situation, response to the remedy, and whether or not you take some other diabetes medicines. Your physician will change your medicine based mostly on your blood sugar. Follow your physician’s directions to the letter.

To obtain the best profit from this drug, take it each day. It’s vital to remember to make use of it at the same time day by day.

If you are already taking a diabetes medicine (resembling metformin or a sulfonylurea), fastidiously comply with your physician’s directions for stopping/persisting with the previous one and beginning with this one. Follow your physician’s medicine remedy routine, meal plan, and exercise programme to the letter.

As suggested by your physician, test your blood sugar on a frequent basis. Keep track of your findings and inform your physician. If your blood sugar ranges are abnormally excessive or low, inform your physician. It’s possible that your dosage or remedy will have to be adjusted. The whole advantage of this medication could take as much as two to three months to manifest.

It’s conceivable that not all doses and types are lined. The following components will affect the dose, kind, and frequency with which you are taking it:

  • your age
  • The situation is being handled.
  • How extreme your situation is
  • Different medical situations you may have
  • The way you react to the primary dose

Actos Side Effects

Drowsiness shouldn’t be brought on by metformin or pioglitazone oral pills. It could, nonetheless, induce low blood sugar and have different destructive results.

More frequent unwanted side effects

The extra frequent unwanted side effects that happen with metformin and pioglitazone include:

  • diarrhea
  • nausea
  • upset abdomen
  • cold-like signs (higher respiratory tract infection)
  • Swelling in your legs, ankles, or toes (edoema).
  • headache
  • weight acquire

If the antagonistic results are modest, they need to go away in a couple of days or perhaps weeks. If they get extra extreme or don’t go away, seek the advice of your physician or pharmacist.

Serious unwanted side effects

If you experience any major unwanted side effects, contact your physician straight away. If your symptoms are life-threatening or you imagine you’re having a medical emergency, dial the emergency number. The following are examples of great unwanted side effects and related signs:

  • low blood sugar (hypoglycemia).* Symptoms can include:
    • temper adjustments, resembling irritability, anger, or disappointment.
    • confusion
    • lightheadedness
    • dizziness
    • sleepiness
    • blurred imaginative and prescient
    • tingling or numbness in your lips or tongue
    • complications
    • weak spot
    • tiredness
    • lack of coordination.
    • Have nightmares or cry out throughout your sleep.
    • seizures
    • lack of consciousness.
  • Lactic acidosis Symptoms can include:
    • weak spot or tiredness.
    • An uncommon muscle ache
    • abdomen pains, nausea, or vomiting
    • respiratory system
    • dizziness or lightheadedness.
    • gradual or irregular coronary heart charge
  • heart failure. Symptoms can include:
    • swelling or fluid retention, particularly in your ankles or legs.
    • shortness of breath or trouble respiration, particularly while you lie down.
    • unusually quick weight acquire
    • Uncommon tiredness
  • Macular edoema (swelling behind your eye) Symptoms can include:
    • blurred imaginative and prescient
  • Anaemia (low crimson blood cell count) Symptoms can include:
    • Pale pores and skin
    • Shortness of breath
    • tiredness
    • Chest ache
  • Bladder most cancers. Symptoms can include:
    • There is blood in your urine.
    • I need to urinate more often than usual.
    • There is an ache in your bladder while you urinate.
  • Broken bones (fractures)
  • Ovulation, which can result in being pregnant,

Treating low blood sugar

You may have a low blood sugar response, and you must deal with it.

  • For gentle hypoglycemia (55–70 mg/dL), the remedy is 15–20 grammes of glucose (a kind of sugar). You have to eat or drink one of many of the following:
    • 3–4 glucose tablets.
    • A tube of glucose gel
    • 12 cup of juice or common, non-diet soda
    • 1 cup of nonfat or 1% cow’s milk
    • 1 tablespoon of sugar, honey, or corn syrup.
    • 8–10 items of laborious sweet, resembling lifesavers
  • Test your blood sugar a quarter-hour after you deal with the low sugar response. If your blood sugar remains low, repeat the above remedy.
  • Once your blood sugar is again within the regular range, eat a small snack in case your subsequent meal or snack is more than 1 hour later.

You can have a seizure, move out, and maybe endure brain injury if you do not handle low blood sugar. Low blood sugar has the potential to be deadly. If you become unconscious or cannot swallow as a consequence of a low sugar response, somebody must inject you with glucagon to remedy the low sugar response. It’s possible that you will have to go to the emergency room.

Pioglitazone Actos Precautions

If you’re allergic to pioglitazone or have some other allergic reaction, notify your physician or pharmacist before taking it. Inactive chemical compounds could also be included in this product, inflicting allergic reactions or different points. For additional information, communicate with your pharmacist.

Tell your physician or pharmacist if you have ever had heart issues (resembling congestive heart failure or chest pain), liver illness, fluid in your lungs, swelling (edoema), anaemia, a selected eye situation (macular edoema), or bladder most cancers earlier than utilising this drug.

You could experience blurred imaginative and prescient, dizziness, or drowsiness if your blood sugar is both low and too excessive. Do not drive, operate equipment, or have interaction in some other exercise that requires alertness or clear imaginative and prescient till you’re assured that you are able to do so safely. Alcohol ought to be avoided when taking this medicine because it will increase the danger of low blood sugar.

When your physique is harassed, controlling your blood sugar could also be tougher (resembling as a consequence of fever, an infection, harm, or surgical procedure). Increased stress could necessitate a change in your remedy plan, medicines, or blood sugar assessments, so discuss it with your physician.

Tell your physician or dentist about all the things you use (together with prescription drugs, over-the-counter medicines, and natural treatments) before the surgical procedure.

In girls, pioglitazone could increase the danger of bone fracture (often in the upper arm, hand, or foot). Also see the notes part.

Pioglitazone can alter your menstrual cycle (promote ovulation) and improve your chances of getting pregnant. While taking this medicine, talk to your physician or pharmacist about utilising a reliable contraception technique.

When being pregnant, this medication ought to be used only when absolutely necessary. Consult your physician concerning the risks and benefits. While you are pregnant, your physician could substitute insulin for this medicine. Pay close consideration to all the instructions.

It is unknown if this medicine goes into breast milk. Before you begin breastfeeding, discuss it with your physician.


Drug interactions could cause your prescriptions to be carried out in another way or put you in danger of harmful antagonistic results. This record doesn’t encompass all potential medical interactions. Keep a list of all the things you utilise (including prescription and nonprescription drugs, in addition to natural merchandise) and focus on it together with your physician and pharmacist. Without your physician’s permission, don’t start, cease, or modify the dosage of any medicine.

Other medications could interfere with the clearance of pioglitazone out of your body, inflicting pioglitazone to function in another way. Gemfibrozil, rifamycins, together with rifampin, are only some examples.

Beta-blocker medications (like metoprolol, propranolol, and glaucoma eye drops like timolol) may help you keep away from the quick, pounding heartbeat that happens when your blood sugar goes too low (hypoglycemia). These medicines have little impact on different signs of low blood sugar, such as dizziness, starvation, or sweating.

Many medicines might have an antagonistic impact on your blood sugar, making it tougher to handle. Consult your physician or pharmacist before starting, stopping, or altering any medicine to be taught the way it could affect your blood sugar. Check your blood sugar as prescribed and inform your physician of the outcomes. If you have signs of excessive or low blood sugar, call your physician straight away. (See also the part on Side Effects.) Your diabetic medicine, exercise routine, or weight loss programme could have to be adjusted by your physician.


Low blood sugar can happen if you take an excessive amount of metformin or pioglitazone. You ought to deal with your low blood sugar if you worry you’ve taken an excessive amount of this medicine or if you’re experiencing signs of low blood sugar.

Missed Dose

Take metformin and pioglitazone as quickly as you can in case you miss a dose. If you simply have a couple of hours before your subsequent dose, solely take one capsule at a time.

Pioglitazone Storage

  • Store metformin/pioglitazone at room temperature between 59 °F and 86 °F (15 °C and 30 °C).
  • Keep the bottle utterly closed and the tablets dry at all times.
  • Don’t freeze this drug.
  • Don’t store this medicine in moist or damp areas, resembling loos.

Pfizer shouldn’t be affiliated with this website. The model identify and logos and pictures used are the property of Pfizer. The content material of this website is for informational functions solely. We don’t provide, market or ship medicines ourselves and refer you to respected internet shops on the Internet. Always seek the advice of a doctor when utilizing medicines.

On this web site we don’t promote any medicines and refer guests to trusted Internet suppliers. In this manner, we prevent and one of the best value to individuals many issues and you may simply and legally acquire this highly effective medication.

Frequently requested questions

  1. What is Pioglitazone?

    Metformin (immediate-release) and pioglitazone (extended-release) are both components of the brand-name medications known as Actoplus Met (immediate-release) and Actoplus Met XR. There is also a pill with a generic formulation that is available for immediate release. It’s common knowledge that generic versions of a drug’s active ingredient will save you money over its brand-name equivalent.

  2. What if u take too much Pioglitazone?

    It is possible to experience low blood sugar if you take an excessive amount of metformin or pioglitazone. You should seek treatment for low blood sugar if you suspect that you may have taken an excessive amount of this medication or if you are experiencing symptoms of low blood sugar (see above).

  3. What to do if you miss a dose?

    If you forget to take a dose of metformin or pioglitazone, you should do so as soon as you remember it. Take only one pill with you at that time if you only have a few hours before your next dose.

  4. What if u take too much Pioglitazone?

    In the event of an overdose, you should contact the emergency centre. It’s possible that you need to seek emergency medical attention right away. You should also get in touch with a Poison Control Centre as soon as possible.

  5. How to store Pioglitazone?

    This medication should be kept at room temperature. Keep it between 15 and 30 degrees Celsius (59 and 86 degrees Fahrenheit) and out of the reach of children and animals.

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