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Active ingredient: Promethazine
Brand(s): Phenergan

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What is Phenergan Promethazine

Phenergan is an irregular antipsychotic medicine. Blocks dopamine receptors of CNS as well as conflicts dopamine button in basic gangliya as well as in limbic a component of neoncephalon. It is taken at Hypersensitivity, disorders of hemopoietic system (along with in anamnesis), alcoholic as well as harmful psychosis, myasthenia, comas.

Drug Uses

Phenergan is used to alleviate or stop the signs of hay fever, allergic conjunctivitis (irritation of the attention), and different kinds of allergy or allergic reactions. It works by stopping the results of a substance known as histamine, which is produced by the physique. Histamine may cause itching, sneezing, runny nostril, and watery eyes. It can generally shut up the bronchial tubes (air passages of the lungs) and make respiratory tough .

Phenergan can also be used to stop and management movement illness, nausea, vomiting, and dizziness. In addition, it could be used to assist individuals fall asleep and management their ache or anxiousness earlier than or after surgical procedure or different procedures .

What Should You Discuss To Your Doctor Before Using This Medicine

  1. General: Drugs having anticholinergic properties should be used with caution in patients with narrow-angle glaucoma, prostatic hypertrophy, stenosing peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. Phenergan Suppositories should be used cautiously in persons with cardiovascular disease or with impairment of liver function.
  2. Carcinogenesis, Mutagenesis, Impairment Of Fertility: Long-term animal studies have not been performed to assess the carcinogenic potential of Phenergan, nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug. Phenergan was nonmutagenic in the Salmonella test system of Ames.
  3. Pregnancy Category C: Teratogenic effects have not been demonstrated in rat-feeding studies at doses of 6.25 and 12.5 mg/kg of Phenergan. These doses are from approximately 2.1 to 4.2 times the maximum recommended total daily dose of Phenergan for a 50-kg subject, depending upon the indication for which the drug is prescribed. Daily doses of 25 mg/kg intraperitoneally have been found to produce fetal mortality in rats.
  4. Labor And Delivery: Phenergan may be used alone or as an adjunct to narcotic analgesics during labor and delivery. Limited data suggest that use of Promethazine during labor and delivery does not have an appreciable effect on the duration of labor or delivery and does not increase the risk of need for intervention in the newborn. The effect on later growth and development of the newborn is unknown. 
  5. Nursing Mothers: It is not known whether is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Phenergan Suppositories, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
  6. Pediatric Use: Phenergan Suppositories Are Contraindicated for Use in Pediatric Patients Less Than Two Years of Age. Promethazine Suppositories should be used with caution in pediatric patients 2 years of age and older.
  7. Geriatric Use: Clinical studies of Promethazine formulations did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

Promethazine Drug Interactions

Although sure medicines shouldn’t be used collectively in any respect, in different instances two totally different medicines could also be used collectively even when an interplay may happen. In these instances, your physician might need to change the dose, or different precautions could also be mandatory. When you take this medication, it’s particularly vital that your healthcare skilled know if you’re taking any of the medicines listed under. The following interactions have been chosen on the premise of their potential significance and are usually not essentially all-inclusive.

Using this medication with any of the next medicines shouldn’t be really helpful. Your physician might determine to not deal with you with this medicine or change a number of the different medicines you are taking.

  • Bepridil
  • Bromopride
  • Calcium Oxybate
  • Cisapride
  • Dronedarone
  • Magnesium Oxybate
  • Mesoridazine
  • Pimozide
  • Piperaquine

Other Interactions

Certain medicines shouldn’t be used at or across the time of consuming meals or consuming sure kinds of meals since interactions might happen. Using alcohol or tobacco with sure medicines may trigger conditions to happen. Discuss along with your healthcare skilled using your medication with meals, alcohol, or tobacco.

Other Medical Problems of Promethazine

The presence of different medical issues might have an effect on using this medication. Make certain you inform your physician if in case you have every other medical issues, particularly:

  • Brain illness
  • Breathing or lung issues (e.g., bronchial asthma)
  • Comatose state (unconscious)
  • Reye’s syndrome 
  • Sleep apnea
  • Bone marrow illness
  • Enlarged prostate
  • Glaucoma 
  • Heart or blood vessel illness
  • Intestinal tract obstruction 
  • Jaundice
  • Liver illness 
  • Neuroleptic malignant syndrome
  • Stomach ulcer
  • Urinary tract blockage or tough urination.
  • Seizure problems

Phenergan Proper Usage

Make sure to take Promethazine exactly as directed by your doctor. Follow the directions on the prescription label to the letter. Your doctor may adjust your dose from time to time to ensure that you get the best results possible. Never take this medication in larger or smaller amounts or for a longer period of time than prescribed.

When to take?

Phenergan is frequently taken before bed or before a meal to help with sleep. When it comes to motion sickness, Phenergan is usually started within 1 hour of leaving the house. Phenergan is typically taken the night before surgery if it is to be used for that purpose.


The frequency with which you take Promethazine, as well as the timing of your dose, will be determined by the condition being treated.

Measure liquid medicine with the dosing syringe that is provided, or with a special dose-measuring spoon or medicine cup that has been specially designed for this purpose. Obtain a dose measuring device from your pharmacist if you do not already have one.

When not to use?

  • if a child is taking this medication, inform your doctor if the child’s weight has changed during treatment. Promethazine doses for children are calculated based on their weight, and any changes in weight may have an impact on your child’s dose.
  • If your symptoms do not improve or if they worsen while you are taking Promethazine, contact your doctor immediately.

Promethazine Dosage

The dose of this medication can be totally different for various sufferers. Follow your physician’s orders or the instructions on the label. The following info consists of solely the common doses of this medication. If your dose is totally different, don’t change it until your physician tells you to take action.

The quantity of medication that you simply take will depend on the energy of the medication. Also, the variety of doses you are taking every day, the time allowed between doses, and the size of time you are taking the medication rely on the medical drawback for which you might be utilizing the medication.

  • For oral dosage kind (tablets):
    • For allergy signs:
      • Adults and youngsters: 12.5 milligrams (mg) earlier than meals and at bedtime; or 25 mg at bedtime as wanted.
      • Children 2 years of age and older: Your physician will decide dose based mostly on the load and/or measurement of the kid. The dose is normally 6.25 to 12.5 mg 3 times a day; or 25 mg at bedtime as wanted.
      • Children youthful than 2 years of age: Use and dose should be decided by your physician .
    • For prevention of movement illness:
      • Adults and youngsters: 25 mg twice each day; this preliminary dose needs to be taken one-half to at least one hour earlier than touring. The dose could also be repeated eight to 12 hours later if wanted. On different days of journey, 25 mg could also be taken on arising and once more earlier than the night meal.
      • Children 2 years of age and older: Your physician will decide dose based mostly on the load and/or measurement of the kid. The dose is normally 12.5 to 25 mg one-half to at least one hour earlier than touring. The dose could also be repeated eight to 12 hours later if wanted.
      • Children youthful than 2 years of age: Use and dose should be decided by your physician .
    • For nausea and vomiting:
      • Adults and youngsters: 25 mg for the primary dose, then 12.5 to 25 mg each 4 to 6 hours if wanted.
      • Children 2 years of age and older: Your physician will decide dose based mostly on the load and/or measurement of the kid. The dose is normally 0.5 mg per pound of physique weight (1.1 mg per kg) or 12.5 to 25 mg each 4 to 6 hours as wanted.
      • Children youthful than 2 years of age: Use and dose should be decided by your physician .
    • For sedation:
      • Adults and youngsters: 25 to 50 mg.
      • Children 2 years of age and older: Your physician will decide dose based mostly on the load and/or measurement of the kid. The dose is normally 12.5 to 25 mg.
      • Children youthful than 2 years of age: Use and dose should be decided by your physician .
    • For management of ache or anxiousness earlier than or after surgical procedure:
      • Adults and youngsters: 50 mg the evening earlier than surgical procedure; 25 to 50 mg after surgical procedure.
      • Children 2 years of age and older: Your physician will decide dose based mostly on the load and/or measurement of the kid. The dose is normally 0.5 mg per pound of physique weight (1.1 mg per kg) or 12.5 to 25 mg the evening earlier than surgical procedure or after the surgical procedure.
      • Children youthful than 2 years of age: Use and dose should be decided by your physician .

Missed dosage

If you miss a dose of this medication, take it as quickly as attainable. However, whether it is nearly time in your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

Phenergan Precautions

It is essential that your physician examine your progress at common visits to verify this medication is working correctly. Blood assessments could also be wanted to examine for side effects .

This medication might have an effect on blood sugar ranges. If you discover a change within the outcomes of your blood or urine sugar assessments or if in case you have any questions, examine along with your physician .

This medication might trigger some individuals to change into dizzy, lightheaded, drowsy, or much less alert than they’re usually. Even if taken at bedtime, it could trigger some individuals to really feel drowsy or much less alert on arising. Make certain you understand how you react to this medication earlier than you drive, use machines, or do anything that could possibly be harmful if you’re not alert .

This medication will add to the results of alcohol and different anti-depressants (medicines that make you drowsy or much less alert). Some examples of mecications are antihistamines or medication for hay fever:

  • different allergy symptoms, or colds
  • sedatives, tranquilizers, antidepressants, or sleeping medication
  • prescription ache medication or narcotics
  • barbiturates
  • medication for seizures
  • muscle relaxants
  • anesthetics
  • dental anesthetics

Check along with your medical physician or dentist earlier than taking any of the above if you are taking this medication.

Phenergan Storage

  1. Store the medication in a closed container at room temperature, away from warmth, moisture, and direct gentle. Keep from freezing.
  2. Ask your healthcare skilled how you need to eliminate any medication you don’t use.
  3. Do not preserve outdated medication or medication now not wanted.
  4. Keep out of the attain of youngsters.

Phenergan Side Effects

Along with its wanted results, a medication might trigger some negative effects. Although not all of those uncomfortable side effects might happen, in the event that they do happen they might want medical consideration.

Stop taking this medication and get emergency assist instantly if any of the next results happen:

  • Convulsions (seizures)
  • tough or unusually quick respiratory
  • quick heartbeat or irregular pulse
  • excessive fever
  • excessive or low (irregular) blood stress
  • elevated sweating
  • lack of bladder management
  • extreme muscle stiffness
  • unusually pale pores and skin
  • uncommon tiredness or weak point

Other negative effects not listed can also happen in some sufferers. If you discover some other results, verify along with your healthcare skilled. Call your physician for medical recommendation about negative effects.

Symptoms of Overdose

  • Discouragement
  • dizziness, faintness, or lightheadedness when getting up from a mendacity or sitting place all of a sudden
  • dry mouth
  • extreme muscle tone
  • feeling of heat
  • feeling unhappy or empty
  • irritability
  • lack of urge for food


Information concerning psychotic disorders, included within the review of Phenergan, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.

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Frequently asked questions

  1. What is Promethazine?

     Phenergan belongs to a group of drugs called phenothiazines. Promethazine is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.

  2. What to do if you miss a dose?

    If you miss a dose of Phenergan, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  3. What if u take too much Phenergan?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  4. How to store Promethazine?

    Store at room temperature between 59-77 degrees F (15-25 degrees C) away from light and moisture, kids and pets. 

  5. What Should I Avoid While Taking Promethazine?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Promethazine. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  6. What are the side effects of Promethazine?

    The most common side effects may include drowsiness, dizziness; ringing in your ears; double vision; feeling nervous; dry mouth; tired feeling, sleep problems (insomnia)

  7. What are the contraindications?

    Phenergan is not allowed to people who have problems with their liver or kidneys, hypersensitive to any component of this dug.

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