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Active Ingredient: Tolterodine
Brand(s): Detrol

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What is Tolterodine

Tolterodine is a aggressive cholinergic receptor antagonist with selectivity for the bladder. It will increase bladder capability, delays the primary urge to urinate and reduces micturition frequency in hyperactive bladder.

Tolterodine Drug Recommendation

For urgency incontinence, bladder retraining is the primary alternative. If insufficiently efficient, assist therapy with a controlled-release oral anticholinergic and/or once-daily dosage (darifenacin, fesoterodine, tolterodine, solifenacin). Commonly focus on whether or not the optimistic impact achieved outweighs the uncomfortable side effects:

  • dry mouth
  • constipation
  • imaginative
  • prescient issues
  • cognitive problems


  • Symptomatic therapy of elevated urgency
  • frequent micturition and/or urgency incontinence
  • overactive bladder syndrome

What Should You Discuss To Your Doctor Before Using This Medicine

  1. Being pregnant
    • Teratogenesis: In people, inadequate knowledge. Indications of harmfulness in animals.
  2. Lactation
    • Transition in breast milk: Unknown.
  3.  Contraindications
      • urinary retention;
      • extreme ulcerative colitis, poisonous megacolon;
      • myasthenia gravis;
      • inadequately regulated narrow-angle glaucoma.

Tolterodine Drug Interactions

Notably in case of ‘poor metabolizers’ watch out when combining with robust CYP3A4 inhibitors:

  • erythromycin
  • clarithromycin
  • ketoconazole
  • itraconazole
  • miconazole
  • HIV protease inhibitors

Additionally watch out when combining with medicines that extend the QT interval

  • quinidine
  • disopyramide
  • sotalol
  • tricyclic antidepressants
  • some antipsychotics
  • macrolide antibiotics
  • fluoroquinolones
  • some antimycotics

Anticholinergic results could also be added when used along with different brokers which have a parasympathetic impact. Tolterodine reduces the impact of brokers that promote gastrointestinal motility. The impact of tolterodine is decreased by parasympathicomimetics.

Tolterodine Dosage

Regardless of variations in pharmacokinetics between ‘ultra-rapid’ and ‘poor metabolisers’ (CYP2D6), the scientific response to the identical dose of tolterodine is comparable in each varieties of sufferers.

  • Elevated urgency, frequent micturition and/or urgency incontinence
    • Adults
      • Really helpful dose: 2 mg 2×/day or 4 mg managed launch capsule (mga) 1×/day. In case of troublesome uncomfortable side effects: 1 mg 2×/day or 2 mg capsule mga 1×/day. After 2-3 months, consider the necessity for additional therapy.
      • In case of impaired hepatic or extreme renal operate (≤ 30 ml/min): 1 mg 2×/day or 2 mg capsule mga 1×/day.
    • Administration: swallow the capsule complete.

Signs of Overdose

  • Relying on severity:
    • lodging problems
    • micturition problems
    • tachycardia
    • respiratory insufficiency
    • central anticholinergic results
      • extreme pleasure
      • hallucinations
    • convulsions

Remedy: If nonetheless helpful, gastric lavage and administration of activated charcoal. Deal with tachycardia with a β-blocker, urinary retention with catheterisation, pronounced agitation or convulsion with a benzodiazepine and extreme central anticholinergic results with physostigmine.

Tolterodine Precautions

Use warning with: important obstruction of the urinary or gastrointestinal tract; additionally with:

  • autonomic neuropathy
  • hiatus hernia
  • renal or hepatic insufficiency

Additionally watch out with threat elements for QT prolongation equivalent to:

  • bradycardia
  • hypokalaemia
  • hypocalcemia
  • hypomagnesemia
  • comedication with medicine that extend QT interval
  • congenital or acquired QT prolongation
  • current cardiac ailments equivalent to:
    • arrhythmia
    • myocardial ischaemia
    • coronary heart failure

The efficacy of tolterodine in youngsters has not been demonstrated. This drugs might have an effect on the flexibility to drive and use machines. 

Detrol Side Effects

  • dry mouth
  • Headache
  • palpitations
  • Dizziness, paraesthesia, drowsiness, fatigue
  • Dry pores and skin
  • Dry eyes, imaginative and prescient impairment, lodging issues
  • Dyspepsia, vomiting, stomach ache, constipation, diarrhoea, flatulence
  • Dysuria, urinary retention
  • Sinusitis, bronchitis
  • Peripheral oedema
  • Weight acquire
  • Chest ache
  • tachycardia
  • arrhythmia
  • coronary heart failure
  • Nervousness, reminiscence loss, improve in dementia
  • Gastro-oesophageal reflux
  • Hypersensitivity

The next have additionally been reported: anaphylactic reactions together with angioedema. Flushing (extreme). Confusion, hallucinations, disorientation. When utilizing the controlled-release capsule, some uncomfortable side effects happen at a decrease frequency.


Information concerning psychotic disorders, included within the review of Tolterodine, is used for the informative features exclusively as well as should not be thought-about to alternative to licensed healthcare or referral of the well being treatment distributor.


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Frequently asked questions

  1. What is Tolterodine Detrol?

    Detrol contains tolterodine tartrate, the substance of cholinergic (acetyl-choline) receptor blockers class. The medication is used to reduce spasms of the bladder muscles, overactive bladder with symptoms of urge urinary incontinence, and frequency.

  2. What to do if you miss a dose?

    If you miss a dose of Tolterodine, take it as quickly as potential. However, whether it is virtually time to your subsequent dose, skip the missed dose and return to your common dosing schedule. Do not double doses.

  3. What if u take too much Zanaflex?

    If an overdose happens, name your physician or call your nearest hospital. You might have pressing medical care. You might also contact the poison management at your local hospital.

  4. How to store Tolterodine?

    Store at room temperature 15-30 C (59-86 F) away from moisture and heat.

  5. What Should I Avoid While Taking Tolterodine?

    Avoid consuming alcohol or utilizing unlawful medicine when you are taking Detrol. They might lower the advantages (e.g. worsen your confusion) and improve hostile results (e.g. sedation) of the remedy.

  6. What are the side effects of Tolterodine Detrol?

    The most common side effects includes chest pain, fast or uneven heart rate, confusion, painful or difficult urination, hallucinations, urinating less than usual or not at all.

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