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Brand names:

  • Topamax®
  • Tablet: 25 mg, 50 mg, 100 mg, 200 mg
  • Sprinkle capsule: 15 mg, 25 mg
  • Trokendi XR®
  • Extended launch capsule: 25 mg, 50 mg, 100 mg, 200 mg

Generic title: topiramate (toe PYRE a mate)

All FDA black field warnings are on the finish of this reality sheet. Please assessment earlier than taking this medicine.

What Is Topiramate And What Does It Treat?

Topamax Topiramate is a medicine that works within the mind and is usually utilized in sufferers with bipolar dysfunction (also referred to as manic melancholy). It is accepted for the therapy of seizures (epilepsy) in adults and youngsters together with different anticonvulsants and for stopping migraine complications in adults. Bipolar dysfunction entails episodes of melancholy and/or mania.

Symptoms of melancholy embody:

  • Depressed temper — feeling unhappy, empty, or tearful
  • Feeling nugatory, responsible, hopeless, or helpless
  • Loss of curiosity or pleasure in regular actions
  • Sleep and eat kind of than normal (for most individuals it’s much less)
  • Low power, bother concentrating, or ideas of demise (suicidal considering)
  • Psychomotor agitation (‘nervous energy’)
  • Psychomotor retardation (feeling like you might be shifting in sluggish movement)

Symptoms of mania embody:

  • Feeling irritable or “high”
  • Having elevated self worth
  • No feeling such as you don’t must sleep
  • The necessity to proceed to speak
  • Feeling like your ideas are too fast (racing ideas)
  • Feeling distracted
  • Concerned in actions which are dangerous or may have dangerous penalties (e.g., extreme spending)

What Is The Most Important Information I Should Know About Topiramate?

Bipolar dysfunction requires long-term therapy. Do not cease taking topiramate even if you really feel higher. With enter from you, your well being care supplier will assess how lengthy you will want to take the medication. Missing doses of topiramate could improve your threat for a relapse in your temper signs.

Do not cease taking topiramate or change your dose with out speaking to along with your healthcare supplier first.
In order for topiramate to work correctly, it must be taken day-after-day as ordered by your healthcare supplier.

Are There Specific Concerns About Topiramate And Pregnancy?

If you might be planning on turning into pregnant, notify your healthcare supplier in order that he/she will finest handle your drugs. People dwelling with bipolar dysfunction who want to grow to be pregnant face vital choices. It is vital to debate the dangers and advantages of therapy along with your physician and caregivers.

Topiramate has been related to an elevated threat of oral cleft start defects. There could also be precautions to lower the danger of this impact. Do not cease taking topiramate with out first talking to your healthcare supplier. Discontinuing comparable drugs throughout being pregnant has been related to a big improve in symptom relapse.

*Breastfeeding just isn’t advisable in ladies who’re taking topiramate.

What Should I Discuss With My Healthcare Provider Before Taking Topiramate?

  • Symptoms of your situation that hassle you probably the most
  • If you’ve ideas of suicide or harming your self
  • Medications you’ve taken up to now on your situation, whether or not they had been efficient or triggered any antagonistic results
  • If you expertise negative effects out of your drugs, focus on them along with your supplier. Some negative effects could cross with time, however others could require modifications within the medicine.
  • Any different psychiatric or medical issues you’ve
  • All different drugs you might be at present taking (together with over-the-counter merchandise, natural and dietary dietary supplements) and any medicine allergy symptoms you’ve
  • Other non-medication therapy you might be receiving, comparable to speak remedy or substance abuse therapy. Your supplier can clarify how these totally different remedies work with the medicine.
  • If you might be pregnant, plan to grow to be pregnant, or are breast-feeding
  • If you drink alcohol or use unlawful medication

How Should I Take Topiramate?

Use a calendar, pillbox, alarm clock, or cellular phone alert that can assist you keep in mind to take your medicine. You might also ask a member of the family or a good friend to remind you or examine in with you to make sure you take your medicine. Further the following the factors that are important when taking:

  • Topiramate is often taken one or two occasions a day with or with out meals.
  • Typically sufferers start at a low dose of medication and the dose is elevated slowly over a number of weeks.
  • The dose often ranges from 25 mg to 400 mg. Only your healthcare supplier can decide the right dose for you.
  • Do not break up or chew tablets as they’ve a bitter style.
  • Sprinkle capsules: Swallow entire or sprinkle onto meals, comparable to applesauce or pudding and eat instantly. Do not chew the sprinkle capsule or contents.
  • Extended-release capsules: Swallow entire. Do not sprinkle on meals, chew, or crush capsule.

What Happens If I Miss A Dose Of Topiramate?

If you miss a dose of topiramate, take it as quickly as you keep in mind, except it’s nearer to the time of your subsequent dose. Discuss this along with your healthcare supplier. Do not double your dose or take greater than what’s prescribed.

What Should I Avoid While Taking Topiramate?

Avoid ingesting alcohol or utilizing unlawful medication when you are taking topiramate. They could lower the advantages (e.g., worsen your signs) and improve antagonistic results (e.g., sedation, dizziness).

What Happens If I Overdose With Topiramate?

If an overdose happens name your physician or emergency number in your country. You may have pressing medical care. You might also contact the poison management heart at your local area.

A particular therapy to reverse the results of topiramate doesn’t exist.

What Are Possible Side Effects Of Topiramate?

Common negative effects

  • Thinking issues: sluggish ideas, bother discovering the correct phrase, confusion, bother concentrating
  • Feel clumsy, unsteady, dizzy, drained, weak, or nervous
  • Loss of urge for food, change in the way in which meals tastes, weight reduction, abdomen ache
  • Numbness or tingling sensation in limbs and extremities

Rare/critical negative effects

  • Mood or habits modifications, comparable to aggression, agitation, apathy, irritability, and melancholy
  • Hearing issues (ringing, buzzing, and decreased listening to)
  • Fever, sore throat, higher respiratory an infection
  • Itching, nosebleeds, pale pores and skin, blisters, allergy (pores and skin rash, swelling, troubled respiration), yellow eyes or pores and skin, simple bruising and bleeding
  • Topiramate could trigger eye issues. Serious eye issues embody a sudden lower in imaginative and prescient with or with out ache/redness and elevated strain within the eye. These eye issues can result in everlasting imaginative and prescient loss if not handled.
  • Topiramate could trigger decreased sweating and elevated physique temperature. People, particularly youngsters, must be watched for indicators of this — particularly in sizzling climates. Some individuals could have to be hospitalized for this situation.
  • Topiramate can improve the extent of acid in your blood (metabolic acidosis). If left untreated, metabolic acidosis may cause brittle or delicate bones, kidney stones, can sluggish the speed of progress in youngsters, and should probably hurt your child in case you are pregnant. Metabolic acidosis can occur with or with out signs. Sometimes individuals with metabolic acidosis will really feel drained, not really feel hungry, really feel modifications in heartbeat, or have bother considering clearly.
  • Studies have discovered that people who take antiepileptic drugs, together with topiramate, have suicidal ideas or behaviors as much as twice as typically as people who take placebo (inactive medicine). These ideas or behaviors occurred in roughly 1 in 500 sufferers taking the antiepileptic class of medicines.

Are There Any Risks For Taking Topiramate For Long Periods Of Time?

To date, there aren’t any recognized issues related to long run use of topiramate. It is a secure and efficient medicine when used as directed.

What Other Medications May Interact With Topiramate?

Topiramate could lower the degrees and results of oral contraceptives (contraception capsules).

The following drugs could lower ranges and results of topiramate: carbamazepine (Tegretol®), phenytoin (Dilantin®), valproate (Depakote®) and phenobarbital

Combining valproate (Depakote®) with topiramate could improve ammonia ranges in your blood. If this occurs, it’s possible you’ll get confused, disoriented, or have problem considering.

Carbonic anhydrase inhibitors, together with acetazolamide, dichlorphenamide, methazolamide, and dorzolamide, improve the danger of kidney stones when taken with topiramate.

How Long Does It Take For Topiramate To Work?

It is essential to inform your physician how you are feeling issues are going through the first few weeks after you begin taking topiramate. It will in all probability take a number of weeks to see large enough modifications in your signs to determine if topiramate is the correct medicine for you.

Mood stabilizer therapy is mostly wanted lifelong for individuals with bipolar dysfunction. Your physician can finest focus on the length of therapy you want primarily based in your signs and course of sickness.

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Frequently asked questions

  1. What is Topiramate?

    Topiramate is a seizure medicine that is used alone or in combination with other medications to prevent and control seizures (epilepsy). These medications can only help you avoid migraine headaches or lessen the number of attacks you have, but they will not help you treat a headache that has already started.

  2. What to do if you miss a dose?

    As soon as possible, take the medicine. Do not combine two dosages at once. If your next Topamax dose is due in less than 6 hours, skip the missed dose.

  3. What if u take too much Topiramate?

    If an overdose happens call the emergency center. You might have pressing medical care. You might also a Poison Control Center immediately.

  4. How to store Topiramate?

    Store this drug at room temperature. Keep it between 59°F to 86°F (15°C to 30°C)..

  5. What Should I Avoid While Taking Topiramate?

    In hot conditions, avoid becoming overheated or dehydrated. Topiramate can cause life-threatening dehydration by raising body temperature and decreasing perspiration (especially in children). Avoid activities like swimming or climbing in high locations that could be dangerous if you suffer a sudden seizure.

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